Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis

Growing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing on the prognosis, upstream regulation mechanism, and immunological roles of UBE2C across diverse tumor types. In this study, we found that UBE2C was elevated in this human pan-can...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiulin Jiang, Yixiao Yuan, Lin Tang, Juan Wang, Qianqian Liu, Xiaolan Zou, Lincan Duan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	epigenetics SNHG1 miRNA-140-3p UBE2C pan-cancer prognosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/faeef51c891e42c6aacf9e299905939a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:faeef51c891e42c6aacf9e299905939a
record_format	dspace
spelling	oai:doaj.org-article:faeef51c891e42c6aacf9e299905939a2021-11-10T07:55:37ZComprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis2296-634X10.3389/fcell.2021.765772https://doaj.org/article/faeef51c891e42c6aacf9e299905939a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.765772/fullhttps://doaj.org/toc/2296-634XGrowing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing on the prognosis, upstream regulation mechanism, and immunological roles of UBE2C across diverse tumor types. In this study, we found that UBE2C was elevated in this human pan-cancer analysis, and high expression of UBE2C was correlated with poor prognosis. In addition, UBE2C expression was markedly associated with tumor mutation burden (TMB), microsatellite instability (MSI), immune cell infiltration, and diverse drug sensitivities. Finally, we showed that the METTL3/SNHG1/miRNA-140-3p axis could potentially regulate UBE2C expression. N(6)-Methyladenosine (m6A) modifications improved the stability of methylated SNHG1 transcripts by decreasing the rate of RNA degradation, which lead to upregulation of SNHG1 in non-small cell lung cancer (NSCLC). In vitro functional experiments showed that SNHG1, as a competing endogenous RNA, sponges miR-140-3p to increase UBE2C expression in NSCLC cell lines. Our study elucidates the clinical importance and regulatory mechanism of the METTL3/SNHG1/miRNA-140-3p/UBE2C axis in NSCLC and provides a prognostic indicator, as well as a promising therapeutic target for patients with NSCLC.Xiulin JiangYixiao YuanLin TangJuan WangQianqian LiuXiaolan ZouLincan DuanFrontiers Media S.A.articleepigeneticsSNHG1miRNA-140-3pUBE2Cpan-cancerprognosisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenetics SNHG1 miRNA-140-3p UBE2C pan-cancer prognosis Biology (General) QH301-705.5
spellingShingle	epigenetics SNHG1 miRNA-140-3p UBE2C pan-cancer prognosis Biology (General) QH301-705.5 Xiulin Jiang Yixiao Yuan Lin Tang Juan Wang Qianqian Liu Xiaolan Zou Lincan Duan Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
description	Growing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing on the prognosis, upstream regulation mechanism, and immunological roles of UBE2C across diverse tumor types. In this study, we found that UBE2C was elevated in this human pan-cancer analysis, and high expression of UBE2C was correlated with poor prognosis. In addition, UBE2C expression was markedly associated with tumor mutation burden (TMB), microsatellite instability (MSI), immune cell infiltration, and diverse drug sensitivities. Finally, we showed that the METTL3/SNHG1/miRNA-140-3p axis could potentially regulate UBE2C expression. N(6)-Methyladenosine (m6A) modifications improved the stability of methylated SNHG1 transcripts by decreasing the rate of RNA degradation, which lead to upregulation of SNHG1 in non-small cell lung cancer (NSCLC). In vitro functional experiments showed that SNHG1, as a competing endogenous RNA, sponges miR-140-3p to increase UBE2C expression in NSCLC cell lines. Our study elucidates the clinical importance and regulatory mechanism of the METTL3/SNHG1/miRNA-140-3p/UBE2C axis in NSCLC and provides a prognostic indicator, as well as a promising therapeutic target for patients with NSCLC.
format	article
author	Xiulin Jiang Yixiao Yuan Lin Tang Juan Wang Qianqian Liu Xiaolan Zou Lincan Duan
author_facet	Xiulin Jiang Yixiao Yuan Lin Tang Juan Wang Qianqian Liu Xiaolan Zou Lincan Duan
author_sort	Xiulin Jiang
title	Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
title_short	Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
title_full	Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
title_fullStr	Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
title_full_unstemmed	Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
title_sort	comprehensive pan-cancer analysis of the prognostic and immunological roles of the mettl3/lncrna-snhg1/mirna-140-3p/ube2c axis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/faeef51c891e42c6aacf9e299905939a
work_keys_str_mv	AT xiulinjiang comprehensivepancanceranalysisoftheprognosticandimmunologicalrolesofthemettl3lncrnasnhg1mirna1403pube2caxis AT yixiaoyuan comprehensivepancanceranalysisoftheprognosticandimmunologicalrolesofthemettl3lncrnasnhg1mirna1403pube2caxis AT lintang comprehensivepancanceranalysisoftheprognosticandimmunologicalrolesofthemettl3lncrnasnhg1mirna1403pube2caxis AT juanwang comprehensivepancanceranalysisoftheprognosticandimmunologicalrolesofthemettl3lncrnasnhg1mirna1403pube2caxis AT qianqianliu comprehensivepancanceranalysisoftheprognosticandimmunologicalrolesofthemettl3lncrnasnhg1mirna1403pube2caxis AT xiaolanzou comprehensivepancanceranalysisoftheprognosticandimmunologicalrolesofthemettl3lncrnasnhg1mirna1403pube2caxis AT lincanduan comprehensivepancanceranalysisoftheprognosticandimmunologicalrolesofthemettl3lncrnasnhg1mirna1403pube2caxis
_version_	1718440434375589888

Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis

Ejemplares similares