Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.

Glycemic control is essential to manage metabolic diseases such as diabetes. Frequent measurements of systemic glucose levels with prompt managements can prevent organ damages. The eye is a glucose highly demanding organ in our body, and the anterior chamber (AC) in the eye has been suggested for a...

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Autores principales:	Toshihide Kurihara, Deokho Lee, Ari Shinojima, Taku Kinoshita, Saori Nishizaki, Yoko Arita, Yuki Hidaka, Yasuyo Nishi, Yoshinori Shirakawa, Sho Kimura, Yukari Tsuneyoshi, Hidemasa Torii, Kazuo Tsubota, Kazuno Negishi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/faf28650fd8648caa91033ea6f325666
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spelling	oai:doaj.org-article:faf28650fd8648caa91033ea6f3256662021-12-02T20:08:39ZGlucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.1932-620310.1371/journal.pone.0256986https://doaj.org/article/faf28650fd8648caa91033ea6f3256662021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256986https://doaj.org/toc/1932-6203Glycemic control is essential to manage metabolic diseases such as diabetes. Frequent measurements of systemic glucose levels with prompt managements can prevent organ damages. The eye is a glucose highly demanding organ in our body, and the anterior chamber (AC) in the eye has been suggested for a noninvasive blood glucose monitoring site. However, calculating blood glucose levels from measuring glucose levels in AC has been difficult and unclear. In this study, we aimed to examine glucose levels from AC and find a correlation with blood glucose levels. A total of 30 patients with cataracts (men and women, study 1; 7 and 3, study 2; 9 and 11) who visited Keio University Hospital from 2015 to 2018 and agreed to participate in this study were recruited. Glucose levels from AC and the blood were examined by a UV-hexokinase or H2O2-electrode method before/during the cataract surgery. These values were analyzed with regression analyses depending on the groups (blood glucose-ascending and descending groups). In the blood glucose-descending group, glucose levels from AC were strongly correlated with blood glucose levels (a high R2 value, 0.8636). However, the relatively moderate correlation was seen in the blood glucose-ascending group (a low R2 value, 0.5228). Taken together, we showed different correlation ratios on glucose levels between AC and the blood, based on blood glucose dynamics. Stacking data regarding this issue would enable establishing noninvasive blood glucose monitoring from measuring glucose levels in AC more correctly, which will be helpful for proper and prompt managements for glucose-mediated complications.Toshihide KuriharaDeokho LeeAri ShinojimaTaku KinoshitaSaori NishizakiYoko AritaYuki HidakaYasuyo NishiYoshinori ShirakawaSho KimuraYukari TsuneyoshiHidemasa ToriiKazuo TsubotaKazuno NegishiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256986 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshihide Kurihara Deokho Lee Ari Shinojima Taku Kinoshita Saori Nishizaki Yoko Arita Yuki Hidaka Yasuyo Nishi Yoshinori Shirakawa Sho Kimura Yukari Tsuneyoshi Hidemasa Torii Kazuo Tsubota Kazuno Negishi Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
description	Glycemic control is essential to manage metabolic diseases such as diabetes. Frequent measurements of systemic glucose levels with prompt managements can prevent organ damages. The eye is a glucose highly demanding organ in our body, and the anterior chamber (AC) in the eye has been suggested for a noninvasive blood glucose monitoring site. However, calculating blood glucose levels from measuring glucose levels in AC has been difficult and unclear. In this study, we aimed to examine glucose levels from AC and find a correlation with blood glucose levels. A total of 30 patients with cataracts (men and women, study 1; 7 and 3, study 2; 9 and 11) who visited Keio University Hospital from 2015 to 2018 and agreed to participate in this study were recruited. Glucose levels from AC and the blood were examined by a UV-hexokinase or H2O2-electrode method before/during the cataract surgery. These values were analyzed with regression analyses depending on the groups (blood glucose-ascending and descending groups). In the blood glucose-descending group, glucose levels from AC were strongly correlated with blood glucose levels (a high R2 value, 0.8636). However, the relatively moderate correlation was seen in the blood glucose-ascending group (a low R2 value, 0.5228). Taken together, we showed different correlation ratios on glucose levels between AC and the blood, based on blood glucose dynamics. Stacking data regarding this issue would enable establishing noninvasive blood glucose monitoring from measuring glucose levels in AC more correctly, which will be helpful for proper and prompt managements for glucose-mediated complications.
format	article
author	Toshihide Kurihara Deokho Lee Ari Shinojima Taku Kinoshita Saori Nishizaki Yoko Arita Yuki Hidaka Yasuyo Nishi Yoshinori Shirakawa Sho Kimura Yukari Tsuneyoshi Hidemasa Torii Kazuo Tsubota Kazuno Negishi
author_facet	Toshihide Kurihara Deokho Lee Ari Shinojima Taku Kinoshita Saori Nishizaki Yoko Arita Yuki Hidaka Yasuyo Nishi Yoshinori Shirakawa Sho Kimura Yukari Tsuneyoshi Hidemasa Torii Kazuo Tsubota Kazuno Negishi
author_sort	Toshihide Kurihara
title	Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
title_short	Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
title_full	Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
title_fullStr	Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
title_full_unstemmed	Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
title_sort	glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/faf28650fd8648caa91033ea6f325666
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Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.

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