A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells

McGovern et al. establish an orthotopic, humanized prostate cancer model to study bone metastasis. The authors demonstrate that a humanized tumor microenvironment (TME) influences the metastatic spread of cancer cells to tissue-engineered bone, highlighting the importance of the TME in prostate canc...

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Autores principales:	Jacqui A. McGovern, Nathalie Bock, Abbas Shafiee, Laure C. Martine, Ferdinand Wagner, Jeremy G. Baldwin, Marietta Landgraf, Christoph A. Lahr, Christoph Meinert, Elizabeth D. Williams, Pamela M. Pollock, Jim Denham, Pamela J. Russell, Gail P. Risbridger, Judith A. Clements, Daniela Loessner, Boris M. Holzapfel, Dietmar W. Hutmacher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/faf5250036f045d891a483661ad13556
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spelling	oai:doaj.org-article:faf5250036f045d891a483661ad135562021-12-02T15:28:56ZA humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells10.1038/s42003-021-02527-x2399-3642https://doaj.org/article/faf5250036f045d891a483661ad135562021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02527-xhttps://doaj.org/toc/2399-3642McGovern et al. establish an orthotopic, humanized prostate cancer model to study bone metastasis. The authors demonstrate that a humanized tumor microenvironment (TME) influences the metastatic spread of cancer cells to tissue-engineered bone, highlighting the importance of the TME in prostate cancer metastasis to bone.Jacqui A. McGovernNathalie BockAbbas ShafieeLaure C. MartineFerdinand WagnerJeremy G. BaldwinMarietta LandgrafChristoph A. LahrChristoph MeinertElizabeth D. WilliamsPamela M. PollockJim DenhamPamela J. RussellGail P. RisbridgerJudith A. ClementsDaniela LoessnerBoris M. HolzapfelDietmar W. HutmacherNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jacqui A. McGovern Nathalie Bock Abbas Shafiee Laure C. Martine Ferdinand Wagner Jeremy G. Baldwin Marietta Landgraf Christoph A. Lahr Christoph Meinert Elizabeth D. Williams Pamela M. Pollock Jim Denham Pamela J. Russell Gail P. Risbridger Judith A. Clements Daniela Loessner Boris M. Holzapfel Dietmar W. Hutmacher A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
description	McGovern et al. establish an orthotopic, humanized prostate cancer model to study bone metastasis. The authors demonstrate that a humanized tumor microenvironment (TME) influences the metastatic spread of cancer cells to tissue-engineered bone, highlighting the importance of the TME in prostate cancer metastasis to bone.
format	article
author	Jacqui A. McGovern Nathalie Bock Abbas Shafiee Laure C. Martine Ferdinand Wagner Jeremy G. Baldwin Marietta Landgraf Christoph A. Lahr Christoph Meinert Elizabeth D. Williams Pamela M. Pollock Jim Denham Pamela J. Russell Gail P. Risbridger Judith A. Clements Daniela Loessner Boris M. Holzapfel Dietmar W. Hutmacher
author_facet	Jacqui A. McGovern Nathalie Bock Abbas Shafiee Laure C. Martine Ferdinand Wagner Jeremy G. Baldwin Marietta Landgraf Christoph A. Lahr Christoph Meinert Elizabeth D. Williams Pamela M. Pollock Jim Denham Pamela J. Russell Gail P. Risbridger Judith A. Clements Daniela Loessner Boris M. Holzapfel Dietmar W. Hutmacher
author_sort	Jacqui A. McGovern
title	A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
title_short	A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
title_full	A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
title_fullStr	A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
title_full_unstemmed	A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
title_sort	humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/faf5250036f045d891a483661ad13556
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A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells

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