Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens

N-acetylcysteine (NAC) is widely used as a mucolytic agent in cases with inflammation of the lungs. NAC is applied in poultry with aflatoxin B1 intoxication as an antioxidant, but its pharmacokinetics are not known. The present study was conducted to characterize the population pharmacokinetics of o...

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Autores principales:	Tsvetelina Petkova, Aneliya Milanova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	poultry N-acetylcysteine pharmacokinetics Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/faf55f97639d4286a2773b8cc1ffbd93
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spelling	oai:doaj.org-article:faf55f97639d4286a2773b8cc1ffbd932021-11-25T19:11:49ZAbsorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens10.3390/vetsci81102442306-7381https://doaj.org/article/faf55f97639d4286a2773b8cc1ffbd932021-10-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/244https://doaj.org/toc/2306-7381N-acetylcysteine (NAC) is widely used as a mucolytic agent in cases with inflammation of the lungs. NAC is applied in poultry with aflatoxin B1 intoxication as an antioxidant, but its pharmacokinetics are not known. The present study was conducted to characterize the population pharmacokinetics of orally administered NAC in broilers. It included 32 chickens, divided into four groups, treated with NAC at a dose rate of 100 mg/kg/day mixed with the feed: healthy broilers (<i>n</i> = 6); chickens infected with <i>Mycoplasma gallisepticum</i> (<i>n</i> = 10); healthy broilers (<i>n</i> = 6); and diseased chickens (<i>n</i> = 10) treated with NAC and doxycycline (via drinking water, 20 mg/kg body weight (b.w.)). Plasma concentrations were analyzed by Liquid Chromatography –Mass Spectrometry (MS)/MS. NAC was absorbed after oral administration in all four groups of chickens. In healthy chickens treated solely with NAC, maximum plasma concentrations of 2.26 ± 0.91 µg mL<sup>−1</sup> were achieved at 2.47 ± 0.45 h after dosing. The value of absorption half-life was 1.04 ± 0.53 h. The population pharmacokinetic analysis showed that dose adjustment of NAC is not required in <i>M. gallisepticum</i>-infected broilers or when it is combined with doxycycline.Tsvetelina PetkovaAneliya MilanovaMDPI AGarticlepoultryN-acetylcysteinepharmacokineticsVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 244, p 244 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	poultry N-acetylcysteine pharmacokinetics Veterinary medicine SF600-1100
spellingShingle	poultry N-acetylcysteine pharmacokinetics Veterinary medicine SF600-1100 Tsvetelina Petkova Aneliya Milanova Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens
description	N-acetylcysteine (NAC) is widely used as a mucolytic agent in cases with inflammation of the lungs. NAC is applied in poultry with aflatoxin B1 intoxication as an antioxidant, but its pharmacokinetics are not known. The present study was conducted to characterize the population pharmacokinetics of orally administered NAC in broilers. It included 32 chickens, divided into four groups, treated with NAC at a dose rate of 100 mg/kg/day mixed with the feed: healthy broilers (<i>n</i> = 6); chickens infected with <i>Mycoplasma gallisepticum</i> (<i>n</i> = 10); healthy broilers (<i>n</i> = 6); and diseased chickens (<i>n</i> = 10) treated with NAC and doxycycline (via drinking water, 20 mg/kg body weight (b.w.)). Plasma concentrations were analyzed by Liquid Chromatography –Mass Spectrometry (MS)/MS. NAC was absorbed after oral administration in all four groups of chickens. In healthy chickens treated solely with NAC, maximum plasma concentrations of 2.26 ± 0.91 µg mL<sup>−1</sup> were achieved at 2.47 ± 0.45 h after dosing. The value of absorption half-life was 1.04 ± 0.53 h. The population pharmacokinetic analysis showed that dose adjustment of NAC is not required in <i>M. gallisepticum</i>-infected broilers or when it is combined with doxycycline.
format	article
author	Tsvetelina Petkova Aneliya Milanova
author_facet	Tsvetelina Petkova Aneliya Milanova
author_sort	Tsvetelina Petkova
title	Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens
title_short	Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens
title_full	Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens
title_fullStr	Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens
title_full_unstemmed	Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens
title_sort	absorption of n-acetylcysteine in healthy and <i>mycoplasma gallisepticum</i>-infected chickens
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/faf55f97639d4286a2773b8cc1ffbd93
work_keys_str_mv	AT tsvetelinapetkova absorptionofnacetylcysteineinhealthyandimycoplasmagallisepticumiinfectedchickens AT aneliyamilanova absorptionofnacetylcysteineinhealthyandimycoplasmagallisepticumiinfectedchickens
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Absorption of N-acetylcysteine in Healthy and <i>Mycoplasma gallisepticum</i>-Infected Chickens

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