Mechanism of the small ATP-independent chaperone Spy is substrate specific

Spy is an ATP independent chaperone that can act as both a holdase and a foldase towards topologically simple substrates. Assessing the interaction of Spy and apoflavodoxin, a complex client, the authors show that Spy’s activity is substrate specific. Spy binds partially unfolded states of apoflavod...

Full description

Saved in:
Bibliographic Details
Main Authors: Rishav Mitra, Varun V. Gadkari, Ben A. Meinen, Carlo P. M. van Mierlo, Brandon T. Ruotolo, James C. A. Bardwell
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/faf6241cffc94273ba8452b252a93b6d
Tags: Add Tag
No Tags, Be the first to tag this record!