Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation

Chia-Chu Chang,1,2 Hung-Hsiang Liou,1 Chia-Lin Wu,1 Chirn-Bin Chang,1,2 Yu-Jun Chang,3 Ping-Fang Chiu,1,2 Ching-Hui Huang41Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3Ep...

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Autores principales:	Chang CC, Liou HH, Wu CL, Chang CB, Chang YJ, Chiu PF, Huang CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Aged atrial fibrillation chronic kidney disease vitamin-K antagonists warfarin Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/faf6938bfe9141f68397a2ededbc90b3
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spelling	oai:doaj.org-article:faf6938bfe9141f68397a2ededbc90b32021-12-02T02:28:28ZWarfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation1178-1998https://doaj.org/article/faf6938bfe9141f68397a2ededbc90b32013-05-01T00:00:00Zhttps://www.dovepress.com/warfarin-slows-deterioration-of-renal-function-in-elderly-patients-wit-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Chia-Chu Chang,1,2 Hung-Hsiang Liou,1 Chia-Lin Wu,1 Chirn-Bin Chang,1,2 Yu-Jun Chang,3 Ping-Fang Chiu,1,2 Ching-Hui Huang41Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3Epidemiology and Biostatistics Center, 4Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, TaiwanBackground: The purpose of this study was to examine whether long-term use of anticoagulants in elderly patients with atrial fibrillation (AF) and chronic kidney disease (CKD) influences renal function.Methods: In this retrospective observational study, we reviewed the records of 2023 patients who attended our institution for treatment of CKD between January 2001 and September 2012. Inclusion criteria were having been under review for three months or more, age older than 60 years, permanent AF, a CHADS2 score > 2, and National Kidney Foundation Kidney Disease Outcomes Quality Initiative CKD stage 3–5. Sixty-one patients fulfilled these criteria, and were divided into those receiving antiplatelet anticoagulation (group A) and those receiving warfarin (group B). The results of laboratory investigations and estimated glomerular filtration rate (GFR) were recorded at months 3, 6, 12, and 18 from treatment initiation. We also recorded the occurrence of serious cardiovascular and neurological events, significant bleeding, and survival beyond 12 years.Results: Of the 61 patients enrolled, 35 were in group A and 26 were in group B. The mean international normalized ratio (INR) was 1.95 ± 1.01 (goal < 3.0). After adjustment for potential confounding variables, we found that patients in group B had a higher estimated GFR (6.06 ± 2.36 mL per minute, P = 0.01). Over a 12-year observation period, group B patients had significantly (P = 0.013) better survival than group A, with an adjusted hazard ratio for mortality of 0.318 (P = 0.022).Conclusion: Warfarin therapy may delay deterioration in renal function and improve survival of elderly patients with CKD and AF.Keywords: aged, atrial fibrillation, chronic kidney disease, vitamin K antagonists, warfarinChang CCLiou HHWu CLChang CBChang YJChiu PFHuang CHDove Medical PressarticleAgedatrial fibrillationchronic kidney diseasevitamin-K antagonistswarfarinGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 523-529 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aged atrial fibrillation chronic kidney disease vitamin-K antagonists warfarin Geriatrics RC952-954.6
spellingShingle	Aged atrial fibrillation chronic kidney disease vitamin-K antagonists warfarin Geriatrics RC952-954.6 Chang CC Liou HH Wu CL Chang CB Chang YJ Chiu PF Huang CH Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation
description	Chia-Chu Chang,1,2 Hung-Hsiang Liou,1 Chia-Lin Wu,1 Chirn-Bin Chang,1,2 Yu-Jun Chang,3 Ping-Fang Chiu,1,2 Ching-Hui Huang41Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3Epidemiology and Biostatistics Center, 4Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, TaiwanBackground: The purpose of this study was to examine whether long-term use of anticoagulants in elderly patients with atrial fibrillation (AF) and chronic kidney disease (CKD) influences renal function.Methods: In this retrospective observational study, we reviewed the records of 2023 patients who attended our institution for treatment of CKD between January 2001 and September 2012. Inclusion criteria were having been under review for three months or more, age older than 60 years, permanent AF, a CHADS2 score > 2, and National Kidney Foundation Kidney Disease Outcomes Quality Initiative CKD stage 3–5. Sixty-one patients fulfilled these criteria, and were divided into those receiving antiplatelet anticoagulation (group A) and those receiving warfarin (group B). The results of laboratory investigations and estimated glomerular filtration rate (GFR) were recorded at months 3, 6, 12, and 18 from treatment initiation. We also recorded the occurrence of serious cardiovascular and neurological events, significant bleeding, and survival beyond 12 years.Results: Of the 61 patients enrolled, 35 were in group A and 26 were in group B. The mean international normalized ratio (INR) was 1.95 ± 1.01 (goal < 3.0). After adjustment for potential confounding variables, we found that patients in group B had a higher estimated GFR (6.06 ± 2.36 mL per minute, P = 0.01). Over a 12-year observation period, group B patients had significantly (P = 0.013) better survival than group A, with an adjusted hazard ratio for mortality of 0.318 (P = 0.022).Conclusion: Warfarin therapy may delay deterioration in renal function and improve survival of elderly patients with CKD and AF.Keywords: aged, atrial fibrillation, chronic kidney disease, vitamin K antagonists, warfarin
format	article
author	Chang CC Liou HH Wu CL Chang CB Chang YJ Chiu PF Huang CH
author_facet	Chang CC Liou HH Wu CL Chang CB Chang YJ Chiu PF Huang CH
author_sort	Chang CC
title	Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation
title_short	Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation
title_full	Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation
title_fullStr	Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation
title_full_unstemmed	Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation
title_sort	warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/faf6938bfe9141f68397a2ededbc90b3
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Warfarin slows deterioration of renal function in elderly patients with chronic kidney disease and atrial fibrillation

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