Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles

Xin-Hua Tian1, Xiao-Ning Lin1, Feng Wei1, Wei Feng1, Zhi-Chun Huang1, Peng Wang1, Lei Ren2, Yi Diao11Department of Neurosurgery, Zhongshan Hospital of Xiamen University, Xiamen, People&#39;s Republic of China; 2Research Center of Biomedical Engineering, Xiamen, People&#39;s Republic...

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Autores principales:	Xin-Hua Tian, Xiao-Ning Lin, Feng Wei, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fafeded1f59b40c4b0e5d5ff7d7b8940
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spelling	oai:doaj.org-article:fafeded1f59b40c4b0e5d5ff7d7b89402021-12-02T02:42:07ZEnhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles1176-91141178-2013https://doaj.org/article/fafeded1f59b40c4b0e5d5ff7d7b89402011-02-01T00:00:00Zhttp://www.dovepress.com/enhanced-brain-targeting-of-temozolomide-in-polysorbate-80-coated-poly-a6431https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Xin-Hua Tian1, Xiao-Ning Lin1, Feng Wei1, Wei Feng1, Zhi-Chun Huang1, Peng Wang1, Lei Ren2, Yi Diao11Department of Neurosurgery, Zhongshan Hospital of Xiamen University, Xiamen, People&#39;s Republic of China; 2Research Center of Biomedical Engineering, Xiamen, People&#39;s Republic of ChinaBackground: Polybutylcyanoacrylate (PBCA) nanoparticles coated with polysorbate-80 have been extensively proposed for delivering drugs into the animal brain and have shown great potential for therapeutic applications. In this study, we made an attempt to deliver the chemotherapeutic drug, temozolomide, into the brain by using PBCA nanoparticles. The physicochemical characteristics, in vitro release, and brain targeting ability of the drug-loaded nanoparticles were investigated.Results: Our results show that a significantly higher concentration of temozolomide in the form of polysorbate-80-coated PBCA nanoparticles was observed in the brain (P &lt; 0.05) in comparison with the free drug.Conclusion: This study indicates that polysorbate-80 coated PBCA nanoparticles could be a feasible carrier for temozolomide delivery to the brain. It is anticipated that the developed formulation may improve on targeted therapy for malignant brain tumors in the future.Keywords: temozolomide, polybutylcyanoacrylate, nanoparticles, polysorbate-80, brain targeting&nbsp; Xin-Hua TianXiao-Ning LinFeng Weiet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 445-452 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xin-Hua Tian Xiao-Ning Lin Feng Wei et al Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
description	Xin-Hua Tian1, Xiao-Ning Lin1, Feng Wei1, Wei Feng1, Zhi-Chun Huang1, Peng Wang1, Lei Ren2, Yi Diao11Department of Neurosurgery, Zhongshan Hospital of Xiamen University, Xiamen, People&#39;s Republic of China; 2Research Center of Biomedical Engineering, Xiamen, People&#39;s Republic of ChinaBackground: Polybutylcyanoacrylate (PBCA) nanoparticles coated with polysorbate-80 have been extensively proposed for delivering drugs into the animal brain and have shown great potential for therapeutic applications. In this study, we made an attempt to deliver the chemotherapeutic drug, temozolomide, into the brain by using PBCA nanoparticles. The physicochemical characteristics, in vitro release, and brain targeting ability of the drug-loaded nanoparticles were investigated.Results: Our results show that a significantly higher concentration of temozolomide in the form of polysorbate-80-coated PBCA nanoparticles was observed in the brain (P &lt; 0.05) in comparison with the free drug.Conclusion: This study indicates that polysorbate-80 coated PBCA nanoparticles could be a feasible carrier for temozolomide delivery to the brain. It is anticipated that the developed formulation may improve on targeted therapy for malignant brain tumors in the future.Keywords: temozolomide, polybutylcyanoacrylate, nanoparticles, polysorbate-80, brain targeting&nbsp;
format	article
author	Xin-Hua Tian Xiao-Ning Lin Feng Wei et al
author_facet	Xin-Hua Tian Xiao-Ning Lin Feng Wei et al
author_sort	Xin-Hua Tian
title	Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
title_short	Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
title_full	Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
title_fullStr	Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
title_full_unstemmed	Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
title_sort	enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/fafeded1f59b40c4b0e5d5ff7d7b8940
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Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles

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