Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density

ABSTRACT Osteoporosis is a disorder of bone remodeling leading to reduced bone mass, structural deterioration, and increased bone fragility. The established diagnosis is based on the measurement of areal bone mineral density by dual‐energy X‐ray absorptiometry (DXA), which poorly captures individual...

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Autores principales:	Gabriele Armbrecht, Huong Nguyen Minh, Jonas Massmann, Kay Raum
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	CORTICAL BONE FRACTURE DISCRIMINATION CLINICAL TRIAL DXA QUANTITATIVE BONE ULTRASOUND Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/faff5f0b505f4642aded0582a87d518b
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spelling	oai:doaj.org-article:faff5f0b505f4642aded0582a87d518b2021-11-04T12:00:57ZPore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density2473-403910.1002/jbm4.10536https://doaj.org/article/faff5f0b505f4642aded0582a87d518b2021-11-01T00:00:00Zhttps://doi.org/10.1002/jbm4.10536https://doaj.org/toc/2473-4039ABSTRACT Osteoporosis is a disorder of bone remodeling leading to reduced bone mass, structural deterioration, and increased bone fragility. The established diagnosis is based on the measurement of areal bone mineral density by dual‐energy X‐ray absorptiometry (DXA), which poorly captures individual bone loss and structural decay. Enlarged cortical pores in the tibia have been proposed to indicate structural deterioration and reduced bone strength in the hip. Here, we report for the first time the in vivo assessment of the cortical pore‐size distribution together with frequency‐dependent attenuation at the anteromedial tibia midshaft by means of a novel ultrasonic cortical backscatter (CortBS) technology. We hypothesized that the CortBS parameters are associated with the occurrence of fragility fractures in postmenopausal women (n = 55). The discrimination performance was compared with those of DXA and high‐resolution peripheral computed tomography (HR‐pQCT). The results suggest a superior discrimination performance of CortBS (area under the receiver operating characteristic curve [AUC]: 0.69 ≤ AUC ≤ 0.75) compared with DXA (0.54 ≤ AUC ≤ 0.55) and a similar performance compared with HR‐pQCT (0.66 ≤ AUC ≤ 0.73). CortBS is the first quantitative bone imaging modality that can quantify microstructural tissue deteriorations in cortical bone, which occur during normal aging and the development of osteoporosis. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.Gabriele ArmbrechtHuong Nguyen MinhJonas MassmannKay RaumWileyarticleCORTICAL BONEFRACTURE DISCRIMINATIONCLINICAL TRIALDXAQUANTITATIVE BONE ULTRASOUNDOrthopedic surgeryRD701-811Diseases of the musculoskeletal systemRC925-935ENJBMR Plus, Vol 5, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CORTICAL BONE FRACTURE DISCRIMINATION CLINICAL TRIAL DXA QUANTITATIVE BONE ULTRASOUND Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	CORTICAL BONE FRACTURE DISCRIMINATION CLINICAL TRIAL DXA QUANTITATIVE BONE ULTRASOUND Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935 Gabriele Armbrecht Huong Nguyen Minh Jonas Massmann Kay Raum Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density
description	ABSTRACT Osteoporosis is a disorder of bone remodeling leading to reduced bone mass, structural deterioration, and increased bone fragility. The established diagnosis is based on the measurement of areal bone mineral density by dual‐energy X‐ray absorptiometry (DXA), which poorly captures individual bone loss and structural decay. Enlarged cortical pores in the tibia have been proposed to indicate structural deterioration and reduced bone strength in the hip. Here, we report for the first time the in vivo assessment of the cortical pore‐size distribution together with frequency‐dependent attenuation at the anteromedial tibia midshaft by means of a novel ultrasonic cortical backscatter (CortBS) technology. We hypothesized that the CortBS parameters are associated with the occurrence of fragility fractures in postmenopausal women (n = 55). The discrimination performance was compared with those of DXA and high‐resolution peripheral computed tomography (HR‐pQCT). The results suggest a superior discrimination performance of CortBS (area under the receiver operating characteristic curve [AUC]: 0.69 ≤ AUC ≤ 0.75) compared with DXA (0.54 ≤ AUC ≤ 0.55) and a similar performance compared with HR‐pQCT (0.66 ≤ AUC ≤ 0.73). CortBS is the first quantitative bone imaging modality that can quantify microstructural tissue deteriorations in cortical bone, which occur during normal aging and the development of osteoporosis. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
format	article
author	Gabriele Armbrecht Huong Nguyen Minh Jonas Massmann Kay Raum
author_facet	Gabriele Armbrecht Huong Nguyen Minh Jonas Massmann Kay Raum
author_sort	Gabriele Armbrecht
title	Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density
title_short	Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density
title_full	Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density
title_fullStr	Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density
title_full_unstemmed	Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density
title_sort	pore‐size distribution and frequency‐dependent attenuation in human cortical tibia bone discriminate fragility fractures in postmenopausal women with low bone mineral density
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/faff5f0b505f4642aded0582a87d518b
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Pore‐Size Distribution and Frequency‐Dependent Attenuation in Human Cortical Tibia Bone Discriminate Fragility Fractures in Postmenopausal Women With Low Bone Mineral Density

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