Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and identify potential kinase targets to overcome GSI resist...

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Autores principales:	Giulia Franciosa, Jos G. A. Smits, Sonia Minuzzo, Ana Martinez-Val, Stefano Indraccolo, Jesper V. Olsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a
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spelling	oai:doaj.org-article:fb005241b37140cb8b362c5dec3d935a2021-12-02T14:49:22ZProteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures10.1038/s41467-021-22787-92041-1723https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22787-9https://doaj.org/toc/2041-1723NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and identify potential kinase targets to overcome GSI resistance.Giulia FranciosaJos G. A. SmitsSonia MinuzzoAna Martinez-ValStefano IndraccoloJesper V. OlsenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Franciosa Jos G. A. Smits Sonia Minuzzo Ana Martinez-Val Stefano Indraccolo Jesper V. Olsen Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
description	NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and identify potential kinase targets to overcome GSI resistance.
format	article
author	Giulia Franciosa Jos G. A. Smits Sonia Minuzzo Ana Martinez-Val Stefano Indraccolo Jesper V. Olsen
author_facet	Giulia Franciosa Jos G. A. Smits Sonia Minuzzo Ana Martinez-Val Stefano Indraccolo Jesper V. Olsen
author_sort	Giulia Franciosa
title	Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
title_short	Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
title_full	Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
title_fullStr	Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
title_full_unstemmed	Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
title_sort	proteomics of resistance to notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a
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Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

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