Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers

Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers

Abstract Background Adoptive transfer of chimeric antigen receptor (CAR)-engineered T cells combined with checkpoint inhibition may prevent T cell exhaustion and improve clinical outcomes. However, the approach is limited by cumulative costs and toxicities. Methods To overcome this drawback, we crea...

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Autores principales: Zhifen Yang, Lingyu Li, Ahu Turkoz, Pohan Chen, Rona Harari-Steinfeld, Maggie Bobbin, Ofir Stefanson, Hana Choi, Violena Pietrobon, Bennett Alphson, Angshumala Goswami, Vitaly Balan, Alper Kearney, Dharmesh Patel, Jin Yang, Damla Inel, Veena Vinod, Alessandra Cesano, Bing Wang, Kyung-Ho Roh, Lei S. Qi, Francesco M. Marincola
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Medicine
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Acceso en línea:https://doaj.org/article/fb0228a28866446a85e61c3402715418
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https://doaj.org/article/fb0228a28866446a85e61c3402715418

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