Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides

Ring-opening polymerizations of α-amino acid N-carboxyanhydrides to form polypeptides are usually sensitive to moisture, slow and can undergo side reactions. Here the authors use lithium hexamethyldisilazide to initiate α-amino acid N-carboxyanhydride polymerizations that is very fast and can be con...

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Autores principales:	Yueming Wu, Danfeng Zhang, Pengcheng Ma, Ruiyi Zhou, Lei Hua, Runhui Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb05258972ab45978d561f3a9a64025d
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spelling	oai:doaj.org-article:fb05258972ab45978d561f3a9a64025d2021-12-02T16:49:34ZLithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides10.1038/s41467-018-07711-y2041-1723https://doaj.org/article/fb05258972ab45978d561f3a9a64025d2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07711-yhttps://doaj.org/toc/2041-1723Ring-opening polymerizations of α-amino acid N-carboxyanhydrides to form polypeptides are usually sensitive to moisture, slow and can undergo side reactions. Here the authors use lithium hexamethyldisilazide to initiate α-amino acid N-carboxyanhydride polymerizations that is very fast and can be conducted in an open vessel.Yueming WuDanfeng ZhangPengcheng MaRuiyi ZhouLei HuaRunhui LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yueming Wu Danfeng Zhang Pengcheng Ma Ruiyi Zhou Lei Hua Runhui Liu Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
description	Ring-opening polymerizations of α-amino acid N-carboxyanhydrides to form polypeptides are usually sensitive to moisture, slow and can undergo side reactions. Here the authors use lithium hexamethyldisilazide to initiate α-amino acid N-carboxyanhydride polymerizations that is very fast and can be conducted in an open vessel.
format	article
author	Yueming Wu Danfeng Zhang Pengcheng Ma Ruiyi Zhou Lei Hua Runhui Liu
author_facet	Yueming Wu Danfeng Zhang Pengcheng Ma Ruiyi Zhou Lei Hua Runhui Liu
author_sort	Yueming Wu
title	Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
title_short	Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
title_full	Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
title_fullStr	Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
title_full_unstemmed	Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
title_sort	lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid n-carboxyanhydrides
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb05258972ab45978d561f3a9a64025d
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Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides

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