A 3D analysis of growth trajectory and integration during early human prenatal facial growth

Abstract Significant shape changes in the human facial skeleton occur in the early prenatal period, and understanding this process is critical for studying a myriad of congenital facial anomalies. However, quantifying and visualizing human fetal facial growth has been challenging. Here, we applied q...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Motoki Katsube, Shigehito Yamada, Natsuko Utsunomiya, Yutaka Yamaguchi, Tetsuya Takakuwa, Akira Yamamoto, Hirohiko Imai, Atsushi Saito, Siddharth R. Vora, Naoki Morimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb0572af0d464632862945257c97edd1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fb0572af0d464632862945257c97edd1
record_format	dspace
spelling	oai:doaj.org-article:fb0572af0d464632862945257c97edd12021-12-02T17:04:05ZA 3D analysis of growth trajectory and integration during early human prenatal facial growth10.1038/s41598-021-85543-52045-2322https://doaj.org/article/fb0572af0d464632862945257c97edd12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85543-5https://doaj.org/toc/2045-2322Abstract Significant shape changes in the human facial skeleton occur in the early prenatal period, and understanding this process is critical for studying a myriad of congenital facial anomalies. However, quantifying and visualizing human fetal facial growth has been challenging. Here, we applied quantitative geometric morphometrics (GM) to high-resolution magnetic resonance images of human embryo and fetuses, to comprehensively analyze facial growth. We utilized non-linear growth estimation and GM methods to assess integrated epigenetic growth between masticatory muscles and associated bones. Our results show that the growth trajectory of the human face in the early prenatal period follows a curved line with three flexion points. Significant antero-posterior development occurs early, resulting in a shift from a mandibular prognathic to relatively orthognathic appearance, followed by expansion in the lateral direction. Furthermore, during this time, the development of the zygoma and the mandibular ramus is closely integrated with the masseter muscle.Motoki KatsubeShigehito YamadaNatsuko UtsunomiyaYutaka YamaguchiTetsuya TakakuwaAkira YamamotoHirohiko ImaiAtsushi SaitoSiddharth R. VoraNaoki MorimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Motoki Katsube Shigehito Yamada Natsuko Utsunomiya Yutaka Yamaguchi Tetsuya Takakuwa Akira Yamamoto Hirohiko Imai Atsushi Saito Siddharth R. Vora Naoki Morimoto A 3D analysis of growth trajectory and integration during early human prenatal facial growth
description	Abstract Significant shape changes in the human facial skeleton occur in the early prenatal period, and understanding this process is critical for studying a myriad of congenital facial anomalies. However, quantifying and visualizing human fetal facial growth has been challenging. Here, we applied quantitative geometric morphometrics (GM) to high-resolution magnetic resonance images of human embryo and fetuses, to comprehensively analyze facial growth. We utilized non-linear growth estimation and GM methods to assess integrated epigenetic growth between masticatory muscles and associated bones. Our results show that the growth trajectory of the human face in the early prenatal period follows a curved line with three flexion points. Significant antero-posterior development occurs early, resulting in a shift from a mandibular prognathic to relatively orthognathic appearance, followed by expansion in the lateral direction. Furthermore, during this time, the development of the zygoma and the mandibular ramus is closely integrated with the masseter muscle.
format	article
author	Motoki Katsube Shigehito Yamada Natsuko Utsunomiya Yutaka Yamaguchi Tetsuya Takakuwa Akira Yamamoto Hirohiko Imai Atsushi Saito Siddharth R. Vora Naoki Morimoto
author_facet	Motoki Katsube Shigehito Yamada Natsuko Utsunomiya Yutaka Yamaguchi Tetsuya Takakuwa Akira Yamamoto Hirohiko Imai Atsushi Saito Siddharth R. Vora Naoki Morimoto
author_sort	Motoki Katsube
title	A 3D analysis of growth trajectory and integration during early human prenatal facial growth
title_short	A 3D analysis of growth trajectory and integration during early human prenatal facial growth
title_full	A 3D analysis of growth trajectory and integration during early human prenatal facial growth
title_fullStr	A 3D analysis of growth trajectory and integration during early human prenatal facial growth
title_full_unstemmed	A 3D analysis of growth trajectory and integration during early human prenatal facial growth
title_sort	3d analysis of growth trajectory and integration during early human prenatal facial growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb0572af0d464632862945257c97edd1
work_keys_str_mv	AT motokikatsube a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT shigehitoyamada a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT natsukoutsunomiya a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT yutakayamaguchi a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT tetsuyatakakuwa a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT akirayamamoto a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT hirohikoimai a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT atsushisaito a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT siddharthrvora a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT naokimorimoto a3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT motokikatsube 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT shigehitoyamada 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT natsukoutsunomiya 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT yutakayamaguchi 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT tetsuyatakakuwa 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT akirayamamoto 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT hirohikoimai 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT atsushisaito 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT siddharthrvora 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth AT naokimorimoto 3danalysisofgrowthtrajectoryandintegrationduringearlyhumanprenatalfacialgrowth
_version_	1718381886595661824

A 3D analysis of growth trajectory and integration during early human prenatal facial growth

Ejemplares similares