Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>

While understanding macromolecular structural elements and their roles in dictating cellular function is critical to grasp basic concepts in biology, it can be challenging for students to master this content—these elements naturally exist at the nanoscale and are not observable with the naked eye. O...

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Autores principales:	Verónica A. Segarra, Richard J. Chi
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Special aspects of education LC8-6691 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fb066a1bc2e5434393a3c265a64d9c1f
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spelling	oai:doaj.org-article:fb066a1bc2e5434393a3c265a64d9c1f2021-11-15T15:04:14ZCombining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>10.1128/jmbe.v21i3.21611935-78851935-7877https://doaj.org/article/fb066a1bc2e5434393a3c265a64d9c1f2020-01-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/jmbe.v21i3.2161https://doaj.org/toc/1935-7877https://doaj.org/toc/1935-7885While understanding macromolecular structural elements and their roles in dictating cellular function is critical to grasp basic concepts in biology, it can be challenging for students to master this content—these elements naturally exist at the nanoscale and are not observable with the naked eye. Oftentimes this understanding is catalyzed by impactful illustrations and animations found online and in textbooks. In recent years, 3D printing technology has become readily accessible as an additional way to generate models and visualize entities of interest. In this report, we describe and discuss the efficacy of an approach using 3D-printed models in combination with online open-source molecular modeling analyses of the macromolecular structure of p53 to engage students with molecular concepts in cancer cell biology and human health. This pedagogy strategy has been successfully integrated into an upper-level undergraduate course at a primarily undergraduate institution and a graduate biology course at a public research university. We describe the potential benefits while providing tools for others to integrate this strategy into their teaching.Verónica A. SegarraRichard J. ChiAmerican Society for MicrobiologyarticleSpecial aspects of educationLC8-6691Biology (General)QH301-705.5ENJournal of Microbiology & Biology Education, Vol 21, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Special aspects of education LC8-6691 Biology (General) QH301-705.5
spellingShingle	Special aspects of education LC8-6691 Biology (General) QH301-705.5 Verónica A. Segarra Richard J. Chi Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>
description	While understanding macromolecular structural elements and their roles in dictating cellular function is critical to grasp basic concepts in biology, it can be challenging for students to master this content—these elements naturally exist at the nanoscale and are not observable with the naked eye. Oftentimes this understanding is catalyzed by impactful illustrations and animations found online and in textbooks. In recent years, 3D printing technology has become readily accessible as an additional way to generate models and visualize entities of interest. In this report, we describe and discuss the efficacy of an approach using 3D-printed models in combination with online open-source molecular modeling analyses of the macromolecular structure of p53 to engage students with molecular concepts in cancer cell biology and human health. This pedagogy strategy has been successfully integrated into an upper-level undergraduate course at a primarily undergraduate institution and a graduate biology course at a public research university. We describe the potential benefits while providing tools for others to integrate this strategy into their teaching.
format	article
author	Verónica A. Segarra Richard J. Chi
author_facet	Verónica A. Segarra Richard J. Chi
author_sort	Verónica A. Segarra
title	Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>
title_short	Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>
title_full	Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>
title_fullStr	Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>
title_full_unstemmed	Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>
title_sort	combining 3d-printed models and open source molecular modeling of p53 to engage students with concepts in cell biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/fb066a1bc2e5434393a3c265a64d9c1f
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Combining 3D-Printed Models and Open Source Molecular Modeling of p53 To Engage Students with Concepts in Cell Biology<sup><xref ref-type="fn" rid="fn1-jmbe-21-72">†</xref></sup>

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