Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

Animal models that fully recapitulate human CCM pathogenesis are not currently available. Here, the authors establish a novel CCM model and reveal that caveolae-Tie2 signaling is involved in CCMs formation at the level of venules, which is accompanied by gradual dissociation of pericytes.

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Autores principales:	Huanjiao Jenny Zhou, Lingfeng Qin, Quan Jiang, Katie N. Murray, Haifeng Zhang, Busu Li, Qun Lin, Morven Graham, Xinran Liu, Jaime Grutzendler, Wang Min
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb06cd85440d49b9be758e802813c193
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spelling	oai:doaj.org-article:fb06cd85440d49b9be758e802813c1932021-12-02T13:24:33ZCaveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model10.1038/s41467-020-20774-02041-1723https://doaj.org/article/fb06cd85440d49b9be758e802813c1932021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20774-0https://doaj.org/toc/2041-1723Animal models that fully recapitulate human CCM pathogenesis are not currently available. Here, the authors establish a novel CCM model and reveal that caveolae-Tie2 signaling is involved in CCMs formation at the level of venules, which is accompanied by gradual dissociation of pericytes.Huanjiao Jenny ZhouLingfeng QinQuan JiangKatie N. MurrayHaifeng ZhangBusu LiQun LinMorven GrahamXinran LiuJaime GrutzendlerWang MinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huanjiao Jenny Zhou Lingfeng Qin Quan Jiang Katie N. Murray Haifeng Zhang Busu Li Qun Lin Morven Graham Xinran Liu Jaime Grutzendler Wang Min Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
description	Animal models that fully recapitulate human CCM pathogenesis are not currently available. Here, the authors establish a novel CCM model and reveal that caveolae-Tie2 signaling is involved in CCMs formation at the level of venules, which is accompanied by gradual dissociation of pericytes.
format	article
author	Huanjiao Jenny Zhou Lingfeng Qin Quan Jiang Katie N. Murray Haifeng Zhang Busu Li Qun Lin Morven Graham Xinran Liu Jaime Grutzendler Wang Min
author_facet	Huanjiao Jenny Zhou Lingfeng Qin Quan Jiang Katie N. Murray Haifeng Zhang Busu Li Qun Lin Morven Graham Xinran Liu Jaime Grutzendler Wang Min
author_sort	Huanjiao Jenny Zhou
title	Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
title_short	Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
title_full	Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
title_fullStr	Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
title_full_unstemmed	Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
title_sort	caveolae-mediated tie2 signaling contributes to ccm pathogenesis in a brain endothelial cell-specific pdcd10-deficient mouse model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb06cd85440d49b9be758e802813c193
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Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

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