Transition path times of coupled folding and binding reveal the formation of an encounter complex

How interactions between binding partners form or break is hidden in the transition paths from the encounter to the formation of a stable complex. Here authors use single‐molecule spectroscopy to measure the transition path times for the association of two intrinsically disordered proteins that form...

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Autores principales:	Flurin Sturzenegger, Franziska Zosel, Erik D. Holmstrom, Karin J. Buholzer, Dmitrii E. Makarov, Daniel Nettels, Benjamin Schuler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb0baaec43a44cbeac635378d9bb4a00
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spelling	oai:doaj.org-article:fb0baaec43a44cbeac635378d9bb4a002021-12-02T17:31:29ZTransition path times of coupled folding and binding reveal the formation of an encounter complex10.1038/s41467-018-07043-x2041-1723https://doaj.org/article/fb0baaec43a44cbeac635378d9bb4a002018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07043-xhttps://doaj.org/toc/2041-1723How interactions between binding partners form or break is hidden in the transition paths from the encounter to the formation of a stable complex. Here authors use single‐molecule spectroscopy to measure the transition path times for the association of two intrinsically disordered proteins that form a folded dimer upon binding and identify a metastable encounter complex.Flurin SturzeneggerFranziska ZoselErik D. HolmstromKarin J. BuholzerDmitrii E. MakarovDaniel NettelsBenjamin SchulerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Flurin Sturzenegger Franziska Zosel Erik D. Holmstrom Karin J. Buholzer Dmitrii E. Makarov Daniel Nettels Benjamin Schuler Transition path times of coupled folding and binding reveal the formation of an encounter complex
description	How interactions between binding partners form or break is hidden in the transition paths from the encounter to the formation of a stable complex. Here authors use single‐molecule spectroscopy to measure the transition path times for the association of two intrinsically disordered proteins that form a folded dimer upon binding and identify a metastable encounter complex.
format	article
author	Flurin Sturzenegger Franziska Zosel Erik D. Holmstrom Karin J. Buholzer Dmitrii E. Makarov Daniel Nettels Benjamin Schuler
author_facet	Flurin Sturzenegger Franziska Zosel Erik D. Holmstrom Karin J. Buholzer Dmitrii E. Makarov Daniel Nettels Benjamin Schuler
author_sort	Flurin Sturzenegger
title	Transition path times of coupled folding and binding reveal the formation of an encounter complex
title_short	Transition path times of coupled folding and binding reveal the formation of an encounter complex
title_full	Transition path times of coupled folding and binding reveal the formation of an encounter complex
title_fullStr	Transition path times of coupled folding and binding reveal the formation of an encounter complex
title_full_unstemmed	Transition path times of coupled folding and binding reveal the formation of an encounter complex
title_sort	transition path times of coupled folding and binding reveal the formation of an encounter complex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb0baaec43a44cbeac635378d9bb4a00
work_keys_str_mv	AT flurinsturzenegger transitionpathtimesofcoupledfoldingandbindingrevealtheformationofanencountercomplex AT franziskazosel transitionpathtimesofcoupledfoldingandbindingrevealtheformationofanencountercomplex AT erikdholmstrom transitionpathtimesofcoupledfoldingandbindingrevealtheformationofanencountercomplex AT karinjbuholzer transitionpathtimesofcoupledfoldingandbindingrevealtheformationofanencountercomplex AT dmitriiemakarov transitionpathtimesofcoupledfoldingandbindingrevealtheformationofanencountercomplex AT danielnettels transitionpathtimesofcoupledfoldingandbindingrevealtheformationofanencountercomplex AT benjaminschuler transitionpathtimesofcoupledfoldingandbindingrevealtheformationofanencountercomplex
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Transition path times of coupled folding and binding reveal the formation of an encounter complex

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