ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mingdong Liu, Taoling Zeng, Xin Zhang, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao, Hong-Rui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb0cf4ef163142abb62caefcf0ec80c7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fb0cf4ef163142abb62caefcf0ec80c7
record_format	dspace
spelling	oai:doaj.org-article:fb0cf4ef163142abb62caefcf0ec80c72021-12-02T17:32:16ZATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage10.1038/s41467-018-06556-92041-1723https://doaj.org/article/fb0cf4ef163142abb62caefcf0ec80c72018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06556-9https://doaj.org/toc/2041-1723DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.Mingdong LiuTaoling ZengXin ZhangChunyan LiuZhihui WuLuming YaoChangchuan XieHui XiaQi LinLiping XieDawang ZhouXianming DengHong-Lin ChanTong-Jin ZhaoHong-Rui WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingdong Liu Taoling Zeng Xin Zhang Chunyan Liu Zhihui Wu Luming Yao Changchuan Xie Hui Xia Qi Lin Liping Xie Dawang Zhou Xianming Deng Hong-Lin Chan Tong-Jin Zhao Hong-Rui Wang ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
description	DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.
format	article
author	Mingdong Liu Taoling Zeng Xin Zhang Chunyan Liu Zhihui Wu Luming Yao Changchuan Xie Hui Xia Qi Lin Liping Xie Dawang Zhou Xianming Deng Hong-Lin Chan Tong-Jin Zhao Hong-Rui Wang
author_facet	Mingdong Liu Taoling Zeng Xin Zhang Chunyan Liu Zhihui Wu Luming Yao Changchuan Xie Hui Xia Qi Lin Liping Xie Dawang Zhou Xianming Deng Hong-Lin Chan Tong-Jin Zhao Hong-Rui Wang
author_sort	Mingdong Liu
title	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_short	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_full	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_fullStr	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_full_unstemmed	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
title_sort	atr/chk1 signaling induces autophagy through sumoylated rhob-mediated lysosomal translocation of tsc2 after dna damage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb0cf4ef163142abb62caefcf0ec80c7
work_keys_str_mv	AT mingdongliu atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT taolingzeng atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT xinzhang atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT chunyanliu atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT zhihuiwu atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT lumingyao atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT changchuanxie atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT huixia atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT qilin atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT lipingxie atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT dawangzhou atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT xianmingdeng atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT honglinchan atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT tongjinzhao atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage AT hongruiwang atrchk1signalinginducesautophagythroughsumoylatedrhobmediatedlysosomaltranslocationoftsc2afterdnadamage
_version_	1718380345824378880

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

Ejemplares similares