TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection

Abstract Background Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>...

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Autores principales:	Angélica Menezes Santiago, Ednelza da Silva Graça Amoras, Maria Alice Freitas Queiroz, Simone Regina Souza da Silva Conde, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosário Vallinoto
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	HCV TNF-alpha Interleukin-10 Polymorphism Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/fb1011df9f8f4244bfae954e067597e5
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spelling	oai:doaj.org-article:fb1011df9f8f4244bfae954e067597e52021-11-08T11:18:29ZTNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection10.1186/s12879-021-06835-91471-2334https://doaj.org/article/fb1011df9f8f4244bfae954e067597e52021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06835-9https://doaj.org/toc/1471-2334Abstract Background Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10 -1082A>G polymorphisms in the susceptibility and progress of chronic hepatitis C. Method The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load. Results The polymorphic genotype for the TNFA -308G>A variant was not present in the group of patients with chronic hepatitis C and its absence could be associated with protection against HCV infection (p = 0.0477). Patients with the polymorphic genotype of the IL10 -1082A>G polymorphism had higher HCV viral load than wild-type patients (p = 0.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores. Conclusion Our results suggest the polymorphic genotype at TNFA -308G>A as protective against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A>G variant associated with higher HCV viral load. Further studies must be performed in order to confirm these associations.Angélica Menezes SantiagoEdnelza da Silva Graça AmorasMaria Alice Freitas QueirozSimone Regina Souza da Silva CondeIzaura Maria Vieira Cayres-VallinotoRicardo IshakAntonio Carlos Rosário VallinotoBMCarticleHCVTNF-alphaInterleukin-10PolymorphismInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HCV TNF-alpha Interleukin-10 Polymorphism Infectious and parasitic diseases RC109-216
spellingShingle	HCV TNF-alpha Interleukin-10 Polymorphism Infectious and parasitic diseases RC109-216 Angélica Menezes Santiago Ednelza da Silva Graça Amoras Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Izaura Maria Vieira Cayres-Vallinoto Ricardo Ishak Antonio Carlos Rosário Vallinoto TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection
description	Abstract Background Genetic changes may induce dysregulated cytokine production and affect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-inflammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10 -1082A>G polymorphisms in the susceptibility and progress of chronic hepatitis C. Method The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classification) and HCV viral load. Results The polymorphic genotype for the TNFA -308G>A variant was not present in the group of patients with chronic hepatitis C and its absence could be associated with protection against HCV infection (p = 0.0477). Patients with the polymorphic genotype of the IL10 -1082A>G polymorphism had higher HCV viral load than wild-type patients (p = 0.0428). Neither polymorphism was associated with different levels of necroinflammatory activity or fibrosis scores. Conclusion Our results suggest the polymorphic genotype at TNFA -308G>A as protective against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A>G variant associated with higher HCV viral load. Further studies must be performed in order to confirm these associations.
format	article
author	Angélica Menezes Santiago Ednelza da Silva Graça Amoras Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Izaura Maria Vieira Cayres-Vallinoto Ricardo Ishak Antonio Carlos Rosário Vallinoto
author_facet	Angélica Menezes Santiago Ednelza da Silva Graça Amoras Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Izaura Maria Vieira Cayres-Vallinoto Ricardo Ishak Antonio Carlos Rosário Vallinoto
author_sort	Angélica Menezes Santiago
title	TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection
title_short	TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection
title_full	TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection
title_fullStr	TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection
title_full_unstemmed	TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection
title_sort	tnfa -308g>a and il10 -1082a>g polymorphisms seem to be predictive biomarkers of chronic hcv infection
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fb1011df9f8f4244bfae954e067597e5
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TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection

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