Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models

Alzheimer's disease (AD) is a complex disease that is mediated by numerous factors and manifests in various forms. A systems biology approach to studying AD involves analyses of various body systems, biological scales, environmental elements, and clinical outcomes to understand the genotype to...

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Autores principales:	Brianna Gurdon, Catherine Kaczorowski
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Alzheimer's disease Imaging Systems biology Resilience Precision medicine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/fb11c037c00f463185a10f4c7faf5263
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id	oai:doaj.org-article:fb11c037c00f463185a10f4c7faf5263
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spelling	oai:doaj.org-article:fb11c037c00f463185a10f4c7faf52632021-12-04T04:33:13ZPursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models1095-953X10.1016/j.nbd.2021.105558https://doaj.org/article/fb11c037c00f463185a10f4c7faf52632021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121003077https://doaj.org/toc/1095-953XAlzheimer's disease (AD) is a complex disease that is mediated by numerous factors and manifests in various forms. A systems biology approach to studying AD involves analyses of various body systems, biological scales, environmental elements, and clinical outcomes to understand the genotype to phenotype relationship that potentially drives AD development. Currently, there are many research investigations probing how modifiable and nonmodifiable factors impact AD symptom presentation. This review specifically focuses on how imaging modalities can be integrated into systems biology approaches using model mouse populations to link brain level functional and structural changes to disease onset and progression. Combining imaging and omics data promotes the classification of AD into subtypes and paves the way for precision medicine solutions to prevent and treat AD.Brianna GurdonCatherine KaczorowskiElsevierarticleAlzheimer's diseaseImagingSystems biologyResiliencePrecision medicineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 161, Iss , Pp 105558- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer's disease Imaging Systems biology Resilience Precision medicine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer's disease Imaging Systems biology Resilience Precision medicine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Brianna Gurdon Catherine Kaczorowski Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
description	Alzheimer's disease (AD) is a complex disease that is mediated by numerous factors and manifests in various forms. A systems biology approach to studying AD involves analyses of various body systems, biological scales, environmental elements, and clinical outcomes to understand the genotype to phenotype relationship that potentially drives AD development. Currently, there are many research investigations probing how modifiable and nonmodifiable factors impact AD symptom presentation. This review specifically focuses on how imaging modalities can be integrated into systems biology approaches using model mouse populations to link brain level functional and structural changes to disease onset and progression. Combining imaging and omics data promotes the classification of AD into subtypes and paves the way for precision medicine solutions to prevent and treat AD.
format	article
author	Brianna Gurdon Catherine Kaczorowski
author_facet	Brianna Gurdon Catherine Kaczorowski
author_sort	Brianna Gurdon
title	Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
title_short	Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
title_full	Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
title_fullStr	Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
title_full_unstemmed	Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models
title_sort	pursuit of precision medicine: systems biology approaches in alzheimer's disease mouse models
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/fb11c037c00f463185a10f4c7faf5263
work_keys_str_mv	AT briannagurdon pursuitofprecisionmedicinesystemsbiologyapproachesinalzheimersdiseasemousemodels AT catherinekaczorowski pursuitofprecisionmedicinesystemsbiologyapproachesinalzheimersdiseasemousemodels
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Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models

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