Cytomegalovirus infection in malignant pleural mesothelioma.

Human cytomegalovirus (HCMV) is a highly prevalent herpes virus which persists as a latent infection and has been detected in several different tumor types. HCMV disease is rare but may occur in high-risk settings, often manifesting as a pulmonary infection. To date HCMV has not been investigated in...

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Autores principales:	DeVon Hunter-Schlichting, Karl T Kelsey, Ryan Demmer, Manish Patel, Raphael Bueno, Brock Christensen, Naomi Fujioka, Deepa Kolarseri, Heather H Nelson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb13723d960d4c7a8854dba020916b2b
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spelling	oai:doaj.org-article:fb13723d960d4c7a8854dba020916b2b2021-12-02T20:15:02ZCytomegalovirus infection in malignant pleural mesothelioma.1932-620310.1371/journal.pone.0254136https://doaj.org/article/fb13723d960d4c7a8854dba020916b2b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254136https://doaj.org/toc/1932-6203Human cytomegalovirus (HCMV) is a highly prevalent herpes virus which persists as a latent infection and has been detected in several different tumor types. HCMV disease is rare but may occur in high-risk settings, often manifesting as a pulmonary infection. To date HCMV has not been investigated in malignant pleural mesothelioma (MPM). In a consecutive case series of 144 MPM patients we evaluated two biomarkers of HCMV: IgG serostatus (defined as positive and negative) and DNAemia (>100 copies/mL of cell free HCMV DNA in serum). Approximately half of the MPM patient population was HCMV IgG seropositive (51%). HCMV DNAemia was highly prevalent (79%) in MPM and independent of IgG serostatus. DNAemia levels consistent with high level current infection (>1000 copies/mL serum) were present in 41% of patients. Neither IgG serostatus nor DNAemia were associated with patient survival. In tissues, we observed that HCMV DNA was present in 48% of tumors (n = 40) and only 29% of normal pleural tissue obtained from individuals without malignancy (n = 21). Our results suggest nearly half of MPM patients have a high level current HCMV infection at the time of treatment and that pleural tissue may be a reservoir for latent HCMV infection. These findings warrant further investigation to determine the full spectrum of pulmonary infections in MPM patients, and whether treatment for high level current HCMV infection may improve patient outcomes.DeVon Hunter-SchlichtingKarl T KelseyRyan DemmerManish PatelRaphael BuenoBrock ChristensenNaomi FujiokaDeepa KolarseriHeather H NelsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254136 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q DeVon Hunter-Schlichting Karl T Kelsey Ryan Demmer Manish Patel Raphael Bueno Brock Christensen Naomi Fujioka Deepa Kolarseri Heather H Nelson Cytomegalovirus infection in malignant pleural mesothelioma.
description	Human cytomegalovirus (HCMV) is a highly prevalent herpes virus which persists as a latent infection and has been detected in several different tumor types. HCMV disease is rare but may occur in high-risk settings, often manifesting as a pulmonary infection. To date HCMV has not been investigated in malignant pleural mesothelioma (MPM). In a consecutive case series of 144 MPM patients we evaluated two biomarkers of HCMV: IgG serostatus (defined as positive and negative) and DNAemia (>100 copies/mL of cell free HCMV DNA in serum). Approximately half of the MPM patient population was HCMV IgG seropositive (51%). HCMV DNAemia was highly prevalent (79%) in MPM and independent of IgG serostatus. DNAemia levels consistent with high level current infection (>1000 copies/mL serum) were present in 41% of patients. Neither IgG serostatus nor DNAemia were associated with patient survival. In tissues, we observed that HCMV DNA was present in 48% of tumors (n = 40) and only 29% of normal pleural tissue obtained from individuals without malignancy (n = 21). Our results suggest nearly half of MPM patients have a high level current HCMV infection at the time of treatment and that pleural tissue may be a reservoir for latent HCMV infection. These findings warrant further investigation to determine the full spectrum of pulmonary infections in MPM patients, and whether treatment for high level current HCMV infection may improve patient outcomes.
format	article
author	DeVon Hunter-Schlichting Karl T Kelsey Ryan Demmer Manish Patel Raphael Bueno Brock Christensen Naomi Fujioka Deepa Kolarseri Heather H Nelson
author_facet	DeVon Hunter-Schlichting Karl T Kelsey Ryan Demmer Manish Patel Raphael Bueno Brock Christensen Naomi Fujioka Deepa Kolarseri Heather H Nelson
author_sort	DeVon Hunter-Schlichting
title	Cytomegalovirus infection in malignant pleural mesothelioma.
title_short	Cytomegalovirus infection in malignant pleural mesothelioma.
title_full	Cytomegalovirus infection in malignant pleural mesothelioma.
title_fullStr	Cytomegalovirus infection in malignant pleural mesothelioma.
title_full_unstemmed	Cytomegalovirus infection in malignant pleural mesothelioma.
title_sort	cytomegalovirus infection in malignant pleural mesothelioma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fb13723d960d4c7a8854dba020916b2b
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Cytomegalovirus infection in malignant pleural mesothelioma.

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