SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1,...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chen Kang, Litao Xie, Susheel K. Gunasekar, Anil Mishra, Yanhui Zhang, Saachi Pai, Yiwen Gao, Ashutosh Kumar, Andrew W. Norris, Samuel B. Stephens, Rajan Sah
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/fb15e3d9e7514bb49e37b64c77a65adc
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:fb15e3d9e7514bb49e37b64c77a65adc
record_format	dspace
spelling	oai:doaj.org-article:fb15e3d9e7514bb49e37b64c77a65adc2021-12-02T15:34:48ZSWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia10.1038/s41467-017-02664-02041-1723https://doaj.org/article/fb15e3d9e7514bb49e37b64c77a65adc2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02664-0https://doaj.org/toc/2041-1723Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1, is involved in glucose-stimulated calcium increase and insulin secretion.Chen KangLitao XieSusheel K. GunasekarAnil MishraYanhui ZhangSaachi PaiYiwen GaoAshutosh KumarAndrew W. NorrisSamuel B. StephensRajan SahNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Kang Litao Xie Susheel K. Gunasekar Anil Mishra Yanhui Zhang Saachi Pai Yiwen Gao Ashutosh Kumar Andrew W. Norris Samuel B. Stephens Rajan Sah SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
description	Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1, is involved in glucose-stimulated calcium increase and insulin secretion.
format	article
author	Chen Kang Litao Xie Susheel K. Gunasekar Anil Mishra Yanhui Zhang Saachi Pai Yiwen Gao Ashutosh Kumar Andrew W. Norris Samuel B. Stephens Rajan Sah
author_facet	Chen Kang Litao Xie Susheel K. Gunasekar Anil Mishra Yanhui Zhang Saachi Pai Yiwen Gao Ashutosh Kumar Andrew W. Norris Samuel B. Stephens Rajan Sah
author_sort	Chen Kang
title	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_short	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_full	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_fullStr	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_full_unstemmed	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_sort	swell1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb15e3d9e7514bb49e37b64c77a65adc
work_keys_str_mv	AT chenkang swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT litaoxie swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT susheelkgunasekar swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT anilmishra swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT yanhuizhang swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT saachipai swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT yiwengao swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT ashutoshkumar swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT andrewwnorris swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT samuelbstephens swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia AT rajansah swell1isaglucosesensorregulatingbcellexcitabilityandsystemicglycaemia
_version_	1718386756733108224

SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Similar Items