SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1,...

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Autores principales:	Chen Kang, Litao Xie, Susheel K. Gunasekar, Anil Mishra, Yanhui Zhang, Saachi Pai, Yiwen Gao, Ashutosh Kumar, Andrew W. Norris, Samuel B. Stephens, Rajan Sah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb15e3d9e7514bb49e37b64c77a65adc
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spelling	oai:doaj.org-article:fb15e3d9e7514bb49e37b64c77a65adc2021-12-02T15:34:48ZSWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia10.1038/s41467-017-02664-02041-1723https://doaj.org/article/fb15e3d9e7514bb49e37b64c77a65adc2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02664-0https://doaj.org/toc/2041-1723Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1, is involved in glucose-stimulated calcium increase and insulin secretion.Chen KangLitao XieSusheel K. GunasekarAnil MishraYanhui ZhangSaachi PaiYiwen GaoAshutosh KumarAndrew W. NorrisSamuel B. StephensRajan SahNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Kang Litao Xie Susheel K. Gunasekar Anil Mishra Yanhui Zhang Saachi Pai Yiwen Gao Ashutosh Kumar Andrew W. Norris Samuel B. Stephens Rajan Sah SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
description	Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al. show that the volume-regulated anion channel, SWELL1, is involved in glucose-stimulated calcium increase and insulin secretion.
format	article
author	Chen Kang Litao Xie Susheel K. Gunasekar Anil Mishra Yanhui Zhang Saachi Pai Yiwen Gao Ashutosh Kumar Andrew W. Norris Samuel B. Stephens Rajan Sah
author_facet	Chen Kang Litao Xie Susheel K. Gunasekar Anil Mishra Yanhui Zhang Saachi Pai Yiwen Gao Ashutosh Kumar Andrew W. Norris Samuel B. Stephens Rajan Sah
author_sort	Chen Kang
title	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_short	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_full	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_fullStr	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_full_unstemmed	SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
title_sort	swell1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb15e3d9e7514bb49e37b64c77a65adc
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SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

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