Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.

<h4>Rationale</h4>Each year 1 million persons acquire permanent U.S. residency visas after tuberculosis (TB) screening. Most applicants undergo a 2-stage screening with tuberculin skin test (TST) followed by CXR only if TST-positive at > 5 mm. Due to cross reaction with bacillus Calme...

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Autores principales:	John A Painter, Edward A Graviss, Hoang Hoa Hai, Duong Thi Cam Nhung, Tran Thi Thanh Nga, Ngan P Ha, Kirsten Wall, Le Thien Huong Loan, Matt Parker, Lilia Manangan, Rick O'Brien, Susan A Maloney, R M Hoekstra, Randall Reves
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb17970de0b64aebbde6585c19732915
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spelling	oai:doaj.org-article:fb17970de0b64aebbde6585c197329152021-11-18T08:41:11ZTuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.1932-620310.1371/journal.pone.0082727https://doaj.org/article/fb17970de0b64aebbde6585c197329152013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24367546/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Rationale</h4>Each year 1 million persons acquire permanent U.S. residency visas after tuberculosis (TB) screening. Most applicants undergo a 2-stage screening with tuberculin skin test (TST) followed by CXR only if TST-positive at > 5 mm. Due to cross reaction with bacillus Calmette-Guérin (BCG), TST may yield false positive results in BCG-vaccinated persons. Interferon gamma release assays exclude antigens found in BCG. In Vietnam, like most high TB-prevalence countries, there is universal BCG vaccination at birth.<h4>Objectives</h4>1. Compare the sensitivity of QuantiFERON-TB Gold In-Tube Assay (QFT) and TST for culture-positive pulmonary TB. 2. Compare the age-specific and overall prevalence of positive TST and QFT among applicants with normal and abnormal CXR.<h4>Methods</h4>We obtained TST and QFT results on 996 applicants with abnormal CXR, of whom 132 had TB, and 479 with normal CXR.<h4>Results</h4>The sensitivity for tuberculosis was 86.4% for QFT; 89.4%, 81.1%, and 52.3% for TST at 5, 10, and 15 mm. The estimated prevalence of positive results at age 15-19 years was 22% and 42% for QFT and TST at 10 mm, respectively. The prevalence increased thereafter by 0.7% year of age for TST and 2.1% for QFT, the latter being more consistent with the increase in TB among applicants.<h4>Conclusions</h4>During 2-stage screening, QFT is as sensitive as TST in detecting TB with fewer requiring CXR and being diagnosed with LTBI. These data support the use of QFT over TST in this population.John A PainterEdward A GravissHoang Hoa HaiDuong Thi Cam NhungTran Thi Thanh NgaNgan P HaKirsten WallLe Thien Huong LoanMatt ParkerLilia MananganRick O'BrienSusan A MaloneyR M HoekstraRandall RevesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82727 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q John A Painter Edward A Graviss Hoang Hoa Hai Duong Thi Cam Nhung Tran Thi Thanh Nga Ngan P Ha Kirsten Wall Le Thien Huong Loan Matt Parker Lilia Manangan Rick O'Brien Susan A Maloney R M Hoekstra Randall Reves Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.
description	<h4>Rationale</h4>Each year 1 million persons acquire permanent U.S. residency visas after tuberculosis (TB) screening. Most applicants undergo a 2-stage screening with tuberculin skin test (TST) followed by CXR only if TST-positive at > 5 mm. Due to cross reaction with bacillus Calmette-Guérin (BCG), TST may yield false positive results in BCG-vaccinated persons. Interferon gamma release assays exclude antigens found in BCG. In Vietnam, like most high TB-prevalence countries, there is universal BCG vaccination at birth.<h4>Objectives</h4>1. Compare the sensitivity of QuantiFERON-TB Gold In-Tube Assay (QFT) and TST for culture-positive pulmonary TB. 2. Compare the age-specific and overall prevalence of positive TST and QFT among applicants with normal and abnormal CXR.<h4>Methods</h4>We obtained TST and QFT results on 996 applicants with abnormal CXR, of whom 132 had TB, and 479 with normal CXR.<h4>Results</h4>The sensitivity for tuberculosis was 86.4% for QFT; 89.4%, 81.1%, and 52.3% for TST at 5, 10, and 15 mm. The estimated prevalence of positive results at age 15-19 years was 22% and 42% for QFT and TST at 10 mm, respectively. The prevalence increased thereafter by 0.7% year of age for TST and 2.1% for QFT, the latter being more consistent with the increase in TB among applicants.<h4>Conclusions</h4>During 2-stage screening, QFT is as sensitive as TST in detecting TB with fewer requiring CXR and being diagnosed with LTBI. These data support the use of QFT over TST in this population.
format	article
author	John A Painter Edward A Graviss Hoang Hoa Hai Duong Thi Cam Nhung Tran Thi Thanh Nga Ngan P Ha Kirsten Wall Le Thien Huong Loan Matt Parker Lilia Manangan Rick O'Brien Susan A Maloney R M Hoekstra Randall Reves
author_facet	John A Painter Edward A Graviss Hoang Hoa Hai Duong Thi Cam Nhung Tran Thi Thanh Nga Ngan P Ha Kirsten Wall Le Thien Huong Loan Matt Parker Lilia Manangan Rick O'Brien Susan A Maloney R M Hoekstra Randall Reves
author_sort	John A Painter
title	Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.
title_short	Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.
title_full	Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.
title_fullStr	Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.
title_full_unstemmed	Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.
title_sort	tuberculosis screening by tuberculosis skin test or quantiferon-tb gold in-tube assay among an immigrant population with a high prevalence of tuberculosis and bcg vaccination.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fb17970de0b64aebbde6585c19732915
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Tuberculosis screening by tuberculosis skin test or QuantiFERON-TB Gold In-Tube Assay among an immigrant population with a high prevalence of tuberculosis and BCG vaccination.

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