Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

Abstract Background Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. Objectives To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor...

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Autores principales:	Andrea Corsini, Francesco Dondi, Daria G. Serio, Silvia Zamagni, Stefania Golinelli, Mercedes Fernandez, Federico Fracassi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	calcitriol FGF‐23 hyperadrenocorticism parathyroid hormone urinary calcium excretion vitamin D Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/fb17ebbd53524dcb92ceffe3e895aa1a
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spelling	oai:doaj.org-article:fb17ebbd53524dcb92ceffe3e895aa1a2021-11-30T17:01:03ZCalcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism1939-16760891-664010.1111/jvim.16143https://doaj.org/article/fb17ebbd53524dcb92ceffe3e895aa1a2021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16143https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. Objectives To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FGF‐23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. Animals Twenty‐three client‐owned dogs with NOHC, and 12 client or staff‐owned healthy dogs. Methods Prospective cross‐sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25‐(OH)D, calcitriol and FGF‐23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. Results Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03‐2.44 vs 0.15%, range, 0.06‐0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7‐490 vs 24.6 pg/mL, range, 5.5‐56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25‐(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF‐23 concentrations than controls (316.6 pg/mL, range, 120.8‐575.6 vs 448.7 pg/mL, range, 244.8‐753; P = .03). Conclusions and Clinical Importance Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.Andrea CorsiniFrancesco DondiDaria G. SerioSilvia ZamagniStefania GolinelliMercedes FernandezFederico FracassiWileyarticlecalcitriolFGF‐23hyperadrenocorticismparathyroid hormoneurinary calcium excretionvitamin DVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1265-1273 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcitriol FGF‐23 hyperadrenocorticism parathyroid hormone urinary calcium excretion vitamin D Veterinary medicine SF600-1100
spellingShingle	calcitriol FGF‐23 hyperadrenocorticism parathyroid hormone urinary calcium excretion vitamin D Veterinary medicine SF600-1100 Andrea Corsini Francesco Dondi Daria G. Serio Silvia Zamagni Stefania Golinelli Mercedes Fernandez Federico Fracassi Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
description	Abstract Background Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. Objectives To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FGF‐23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. Animals Twenty‐three client‐owned dogs with NOHC, and 12 client or staff‐owned healthy dogs. Methods Prospective cross‐sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25‐(OH)D, calcitriol and FGF‐23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. Results Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03‐2.44 vs 0.15%, range, 0.06‐0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7‐490 vs 24.6 pg/mL, range, 5.5‐56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25‐(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF‐23 concentrations than controls (316.6 pg/mL, range, 120.8‐575.6 vs 448.7 pg/mL, range, 244.8‐753; P = .03). Conclusions and Clinical Importance Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.
format	article
author	Andrea Corsini Francesco Dondi Daria G. Serio Silvia Zamagni Stefania Golinelli Mercedes Fernandez Federico Fracassi
author_facet	Andrea Corsini Francesco Dondi Daria G. Serio Silvia Zamagni Stefania Golinelli Mercedes Fernandez Federico Fracassi
author_sort	Andrea Corsini
title	Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_short	Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_full	Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_fullStr	Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_full_unstemmed	Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_sort	calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/fb17ebbd53524dcb92ceffe3e895aa1a
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Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

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