Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area

Abstract A serologic test for antibodies to chlamydial antigen pgp3 may be a useful tool for trachoma surveillance. However, little is known about the stability of antibody status over time, or factors associated with seroreversion/conversion. A cohort of 2,111 children ages 1–9 years in Tanzania we...

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Autores principales:	Sheila K. West, Beatriz Munoz, Hemjot Kaur, Laura Dize, Harran Mkocha, Charlotte A. Gaydos, Thomas C. Quinn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb1a952d696d4455955c2d008db3982e
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spelling	oai:doaj.org-article:fb1a952d696d4455955c2d008db3982e2021-12-02T16:08:14ZLongitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area10.1038/s41598-018-21127-02045-2322https://doaj.org/article/fb1a952d696d4455955c2d008db3982e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21127-0https://doaj.org/toc/2045-2322Abstract A serologic test for antibodies to chlamydial antigen pgp3 may be a useful tool for trachoma surveillance. However, little is known about the stability of antibody status over time, or factors associated with seroreversion/conversion. A cohort of 2,111 children ages 1–9 years in Tanzania were followed for one year in the absence of mass azithromycin. At baseline and follow-up, they were evaluated for trachoma, chlamydial infection, and antibodies to chlamydial antigen pgp3. At baseline, 31% of children were seropositive for pgp3 antibodies and 6.4% seroreverted to negative over one year. Of those seronegative, 9.8% seroconverted over the year. The seroreverters had lower baseline mean fluorescence intensity (MFI-BG) values compared to the seropositives who remained positive (Odds Ratio = 0.04 for every unit increase in log10MFI-BG, 95% CI = 0.02–0.09), and were more likely to live in communities with trachoma <5% (p < 0.008). While seroconversion was expected, seroreversion was unexpected. The low seroprevalence rate reported from low endemic areas may be due to seroreversion as well as lack of exposure.Sheila K. WestBeatriz MunozHemjot KaurLaura DizeHarran MkochaCharlotte A. GaydosThomas C. QuinnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sheila K. West Beatriz Munoz Hemjot Kaur Laura Dize Harran Mkocha Charlotte A. Gaydos Thomas C. Quinn Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area
description	Abstract A serologic test for antibodies to chlamydial antigen pgp3 may be a useful tool for trachoma surveillance. However, little is known about the stability of antibody status over time, or factors associated with seroreversion/conversion. A cohort of 2,111 children ages 1–9 years in Tanzania were followed for one year in the absence of mass azithromycin. At baseline and follow-up, they were evaluated for trachoma, chlamydial infection, and antibodies to chlamydial antigen pgp3. At baseline, 31% of children were seropositive for pgp3 antibodies and 6.4% seroreverted to negative over one year. Of those seronegative, 9.8% seroconverted over the year. The seroreverters had lower baseline mean fluorescence intensity (MFI-BG) values compared to the seropositives who remained positive (Odds Ratio = 0.04 for every unit increase in log10MFI-BG, 95% CI = 0.02–0.09), and were more likely to live in communities with trachoma <5% (p < 0.008). While seroconversion was expected, seroreversion was unexpected. The low seroprevalence rate reported from low endemic areas may be due to seroreversion as well as lack of exposure.
format	article
author	Sheila K. West Beatriz Munoz Hemjot Kaur Laura Dize Harran Mkocha Charlotte A. Gaydos Thomas C. Quinn
author_facet	Sheila K. West Beatriz Munoz Hemjot Kaur Laura Dize Harran Mkocha Charlotte A. Gaydos Thomas C. Quinn
author_sort	Sheila K. West
title	Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area
title_short	Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area
title_full	Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area
title_fullStr	Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area
title_full_unstemmed	Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area
title_sort	longitudinal change in the serology of antibodies to chlamydia trachomatis pgp3 in children residing in a trachoma area
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb1a952d696d4455955c2d008db3982e
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Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area

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