Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia

Abstract We tested the hypothesis that five daily sessions of visual cortex transcranial random noise stimulation would improve contrast sensitivity, crowded and uncrowded visual acuity in adults with amblyopia. Nineteen adults with amblyopia (44.2 ± 14.9 years, 10 female) were randomly allocated to...

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Autores principales: Richard Donkor, Andrew E. Silva, Caroline Teske, Margaret Wallis-Duffy, Aaron P. Johnson, Benjamin Thompson
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:fb1b37681c7e42069a81542bf1b02a522021-12-02T14:06:50ZRepetitive visual cortex transcranial random noise stimulation in adults with amblyopia10.1038/s41598-020-80843-82045-2322https://doaj.org/article/fb1b37681c7e42069a81542bf1b02a522021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80843-8https://doaj.org/toc/2045-2322Abstract We tested the hypothesis that five daily sessions of visual cortex transcranial random noise stimulation would improve contrast sensitivity, crowded and uncrowded visual acuity in adults with amblyopia. Nineteen adults with amblyopia (44.2 ± 14.9 years, 10 female) were randomly allocated to active or sham tRNS of the visual cortex (active, n = 9; sham, n = 10). Sixteen participants completed the study (n = 8 per group). tRNS was delivered for 25 min across five consecutive days. Monocular contrast sensitivity, uncrowded and crowded visual acuity were measured before, during, 5 min and 30 min post stimulation on each day. Active tRNS significantly improved contrast sensitivity and uncrowded visual acuity for both amblyopic and fellow eyes whereas sham stimulation had no effect. An analysis of the day by day effects revealed large within session improvements on day 1 for the active group that waned across subsequent days. No long-lasting (multi-day) improvements were observed for contrast sensitivity, however a long-lasting improvement in amblyopic eye uncrowded visual acuity was observed for the active group. This improvement remained at 28 day follow up. However, between-group differences in baseline uncrowded visual acuity complicate the interpretation of this effect. No effect of tRNS was observed for amblyopic eye crowded visual acuity. In agreement with previous non-invasive brain stimulation studies using different techniques, tRNS induced short-term contrast sensitivity improvements in adult amblyopic eyes, however, repeated sessions of tRNS did not lead to enhanced or long-lasting effects for the majority of outcome measures.Richard DonkorAndrew E. SilvaCaroline TeskeMargaret Wallis-DuffyAaron P. JohnsonBenjamin ThompsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Richard Donkor
Andrew E. Silva
Caroline Teske
Margaret Wallis-Duffy
Aaron P. Johnson
Benjamin Thompson
Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia
description Abstract We tested the hypothesis that five daily sessions of visual cortex transcranial random noise stimulation would improve contrast sensitivity, crowded and uncrowded visual acuity in adults with amblyopia. Nineteen adults with amblyopia (44.2 ± 14.9 years, 10 female) were randomly allocated to active or sham tRNS of the visual cortex (active, n = 9; sham, n = 10). Sixteen participants completed the study (n = 8 per group). tRNS was delivered for 25 min across five consecutive days. Monocular contrast sensitivity, uncrowded and crowded visual acuity were measured before, during, 5 min and 30 min post stimulation on each day. Active tRNS significantly improved contrast sensitivity and uncrowded visual acuity for both amblyopic and fellow eyes whereas sham stimulation had no effect. An analysis of the day by day effects revealed large within session improvements on day 1 for the active group that waned across subsequent days. No long-lasting (multi-day) improvements were observed for contrast sensitivity, however a long-lasting improvement in amblyopic eye uncrowded visual acuity was observed for the active group. This improvement remained at 28 day follow up. However, between-group differences in baseline uncrowded visual acuity complicate the interpretation of this effect. No effect of tRNS was observed for amblyopic eye crowded visual acuity. In agreement with previous non-invasive brain stimulation studies using different techniques, tRNS induced short-term contrast sensitivity improvements in adult amblyopic eyes, however, repeated sessions of tRNS did not lead to enhanced or long-lasting effects for the majority of outcome measures.
format article
author Richard Donkor
Andrew E. Silva
Caroline Teske
Margaret Wallis-Duffy
Aaron P. Johnson
Benjamin Thompson
author_facet Richard Donkor
Andrew E. Silva
Caroline Teske
Margaret Wallis-Duffy
Aaron P. Johnson
Benjamin Thompson
author_sort Richard Donkor
title Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia
title_short Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia
title_full Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia
title_fullStr Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia
title_full_unstemmed Repetitive visual cortex transcranial random noise stimulation in adults with amblyopia
title_sort repetitive visual cortex transcranial random noise stimulation in adults with amblyopia
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fb1b37681c7e42069a81542bf1b02a52
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