Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results

Abstract One of the main health problems in many societies is the increased opium abuse, which was found to be correlated with many problems like cardiovascular disease. This study aimed to evaluate the correlation of opium use with blood lipoproteins as the risk factor of CVD. This was a cross-sect...

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Autores principales:	Maryam Kazemi, Mina Bazyar, Mohammad Mehdi Naghizadeh, Azizallah Dehghan, Massih Sedigh Rahimabadi, Mahsa Rostami Chijan, Mostafa Bijani, Maryam Zahmatkeshan, Alireza Ghaemi, Nastaran Samimi, Reza Homayounfar, Mojtaba Farjam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb1c886f404c46a999b3a5002196ec08
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spelling	oai:doaj.org-article:fb1c886f404c46a999b3a5002196ec082021-12-02T14:58:14ZLipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results10.1038/s41598-021-91533-42045-2322https://doaj.org/article/fb1c886f404c46a999b3a5002196ec082021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91533-4https://doaj.org/toc/2045-2322Abstract One of the main health problems in many societies is the increased opium abuse, which was found to be correlated with many problems like cardiovascular disease. This study aimed to evaluate the correlation of opium use with blood lipoproteins as the risk factor of CVD. This was a cross-sectional study conducted on participants of the first phase of the PERSIAN Cohort study who were aged between 35 and 70 years old. Demographic characteristics; history of smoking, alcohol, and opium consumption; medical history; and medications were asked and the related checklists were filled out. The levels of physical activity and fat intake were also registered. As well, lipoprotein profiles were investigated by blood sampling. The linear and logistic regression was used to analyze the relationship between opium and lipid profile and the statistical significant level was considered as < 0.05. Among 9300 participants with a mean age of 48.06 ± 9.44 years old, 49.6% of them were men. About 24.1% of the participants used opium. In the linear regression models, unlike TG (β = 2.2, p = 0.36), total cholesterol (β = − 2.5, p = 0.02), LDL (β = − 2.0, p = 0.04), and HDL (β = − 1.0, p = 0.04) were significantly lower in people who used opium compared to the others. In the logistic regression models, abnormal level of LDL (OR = 0.78, p = 0.003) and total cholesterol (OR = 0.82, p = 0.008) were less in people who used opium compared to the others. This study showed that there is a correlation between opium usage and lower levels of total cholesterol and LDL; however, the lower level of HDL in normal range was seen in opium users. Considering the current evidences, most of them showed the increased risks of ischemic heart disease, heart attack, hypertension, cerebrovascular disease, and cancer in opium users. Therefore, Healthcare providers and patients should be noticed about the deleterious effects of opium consumption on various vascular events. In addition, it is necessary for managers and policy makers of the health care system to take the necessary measures to raise the level of awareness and health literacy of the general public about the high-risk side effects of opium use and to take necessary and effective strategies to prevent and reduce its use.Maryam KazemiMina BazyarMohammad Mehdi NaghizadehAzizallah DehghanMassih Sedigh RahimabadiMahsa Rostami ChijanMostafa BijaniMaryam ZahmatkeshanAlireza GhaemiNastaran SamimiReza HomayounfarMojtaba FarjamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maryam Kazemi Mina Bazyar Mohammad Mehdi Naghizadeh Azizallah Dehghan Massih Sedigh Rahimabadi Mahsa Rostami Chijan Mostafa Bijani Maryam Zahmatkeshan Alireza Ghaemi Nastaran Samimi Reza Homayounfar Mojtaba Farjam Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results
description	Abstract One of the main health problems in many societies is the increased opium abuse, which was found to be correlated with many problems like cardiovascular disease. This study aimed to evaluate the correlation of opium use with blood lipoproteins as the risk factor of CVD. This was a cross-sectional study conducted on participants of the first phase of the PERSIAN Cohort study who were aged between 35 and 70 years old. Demographic characteristics; history of smoking, alcohol, and opium consumption; medical history; and medications were asked and the related checklists were filled out. The levels of physical activity and fat intake were also registered. As well, lipoprotein profiles were investigated by blood sampling. The linear and logistic regression was used to analyze the relationship between opium and lipid profile and the statistical significant level was considered as < 0.05. Among 9300 participants with a mean age of 48.06 ± 9.44 years old, 49.6% of them were men. About 24.1% of the participants used opium. In the linear regression models, unlike TG (β = 2.2, p = 0.36), total cholesterol (β = − 2.5, p = 0.02), LDL (β = − 2.0, p = 0.04), and HDL (β = − 1.0, p = 0.04) were significantly lower in people who used opium compared to the others. In the logistic regression models, abnormal level of LDL (OR = 0.78, p = 0.003) and total cholesterol (OR = 0.82, p = 0.008) were less in people who used opium compared to the others. This study showed that there is a correlation between opium usage and lower levels of total cholesterol and LDL; however, the lower level of HDL in normal range was seen in opium users. Considering the current evidences, most of them showed the increased risks of ischemic heart disease, heart attack, hypertension, cerebrovascular disease, and cancer in opium users. Therefore, Healthcare providers and patients should be noticed about the deleterious effects of opium consumption on various vascular events. In addition, it is necessary for managers and policy makers of the health care system to take the necessary measures to raise the level of awareness and health literacy of the general public about the high-risk side effects of opium use and to take necessary and effective strategies to prevent and reduce its use.
format	article
author	Maryam Kazemi Mina Bazyar Mohammad Mehdi Naghizadeh Azizallah Dehghan Massih Sedigh Rahimabadi Mahsa Rostami Chijan Mostafa Bijani Maryam Zahmatkeshan Alireza Ghaemi Nastaran Samimi Reza Homayounfar Mojtaba Farjam
author_facet	Maryam Kazemi Mina Bazyar Mohammad Mehdi Naghizadeh Azizallah Dehghan Massih Sedigh Rahimabadi Mahsa Rostami Chijan Mostafa Bijani Maryam Zahmatkeshan Alireza Ghaemi Nastaran Samimi Reza Homayounfar Mojtaba Farjam
author_sort	Maryam Kazemi
title	Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results
title_short	Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results
title_full	Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results
title_fullStr	Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results
title_full_unstemmed	Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results
title_sort	lipid profile dysregulation in opium users based on fasa persian cohort study results
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb1c886f404c46a999b3a5002196ec08
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Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results

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