Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.

<h4>Background</h4>Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, wher...

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Autores principales:	María E Sáez, Tarik Smani, Reposo Ramírez-Lorca, Ignacio Díaz, Manuel Serrano-Ríos, Agustín Ruiz, Antonio Ordoñez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb1e3fac5d8147bf8f67fa10bf63db0e
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spelling	oai:doaj.org-article:fb1e3fac5d8147bf8f67fa10bf63db0e2021-11-18T06:54:48ZAssociation analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.1932-620310.1371/journal.pone.0019327https://doaj.org/article/fb1e3fac5d8147bf8f67fa10bf63db0e2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559414/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release.<h4>Objective</h4>Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA).<h4>Results and conclusions</h4>We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, but also in thePER3 gene, located upstream from UTS2. Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.María E SáezTarik SmaniReposo Ramírez-LorcaIgnacio DíazManuel Serrano-RíosAgustín RuizAntonio OrdoñezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e19327 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q María E Sáez Tarik Smani Reposo Ramírez-Lorca Ignacio Díaz Manuel Serrano-Ríos Agustín Ruiz Antonio Ordoñez Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
description	<h4>Background</h4>Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release.<h4>Objective</h4>Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA).<h4>Results and conclusions</h4>We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, but also in thePER3 gene, located upstream from UTS2. Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.
format	article
author	María E Sáez Tarik Smani Reposo Ramírez-Lorca Ignacio Díaz Manuel Serrano-Ríos Agustín Ruiz Antonio Ordoñez
author_facet	María E Sáez Tarik Smani Reposo Ramírez-Lorca Ignacio Díaz Manuel Serrano-Ríos Agustín Ruiz Antonio Ordoñez
author_sort	María E Sáez
title	Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
title_short	Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
title_full	Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
title_fullStr	Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
title_full_unstemmed	Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
title_sort	association analysis of urotensin ii gene (uts2) and flanking regions with biochemical parameters related to insulin resistance.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/fb1e3fac5d8147bf8f67fa10bf63db0e
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Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.

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