Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease

Abstract Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with significant poor outcomes including an increased risk of cardiovascular (CV) events and exercise intolerance. Endothelial dysfunction might contribute to an impaired vascular homeostasis and con...

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Autores principales:	Erika Zavaglia Kabbach, Alessandro Domingues Heubel, Cassia da Luz Goulart, Valéria Amorim Pires Di Lorenzo, Shane A. Phillips, Audrey Borghi-Silva, Renata Gonçalves Mendes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb229bdb28fc48748ff89e70042d7bf9
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spelling	oai:doaj.org-article:fb229bdb28fc48748ff89e70042d7bf92021-12-02T14:12:47ZAssociation of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease10.1038/s41598-020-80601-w2045-2322https://doaj.org/article/fb229bdb28fc48748ff89e70042d7bf92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80601-whttps://doaj.org/toc/2045-2322Abstract Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with significant poor outcomes including an increased risk of cardiovascular (CV) events and exercise intolerance. Endothelial dysfunction might contribute to an impaired vascular homeostasis and consequently to CV events and exercise capacity. This study aimed to evaluate the association between exercise capacity and endothelial function in patients with severe AECOPD. Forty-five COPD patients diagnosed with severe AECOPD and admitted to the University Hospital of São Carlos from 2017 to 2019 were enrolled in this observational clinical study. Endothelial Function was assessed by brachial artery ultrasonography (M-Turbo, Sonosite, Bottle, WA, USA) and Flow Mediated Dilatation (FMD) technique in absolute (mm) and percentage values (%). Walking distance (6MWD) obtained by six-minute walk test was considered to characterize the exercise capacity. Pearson’s correlation analysis and linear regression model were applied and a significance level of 5%. There was a significant positive correlation between exercise capacity and endothelial function. Pearson correlation coefficient were 0.36 (p = 0.02) and 0.40 (p = 0.01) between 6MWD and FMD in mm and %, respectively. Linear regression model revealed 6MWD (p = 0.007), accounting for 15% of FMD (%) variance (R2 adjusted). FMD (%) = 2.11 + (0.0081*6MWD). Exercise capacity is associated with endothelial function in patients with severe AECOPD. FMD was found to be increasing with increasing walked distance. Further research is needed to provide evidence of effectiveness of rehabilitation on exercise capacity and endothelial function in these patients and its prognostic value.Erika Zavaglia KabbachAlessandro Domingues HeubelCassia da Luz GoulartValéria Amorim Pires Di LorenzoShane A. PhillipsAudrey Borghi-SilvaRenata Gonçalves MendesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erika Zavaglia Kabbach Alessandro Domingues Heubel Cassia da Luz Goulart Valéria Amorim Pires Di Lorenzo Shane A. Phillips Audrey Borghi-Silva Renata Gonçalves Mendes Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease
description	Abstract Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with significant poor outcomes including an increased risk of cardiovascular (CV) events and exercise intolerance. Endothelial dysfunction might contribute to an impaired vascular homeostasis and consequently to CV events and exercise capacity. This study aimed to evaluate the association between exercise capacity and endothelial function in patients with severe AECOPD. Forty-five COPD patients diagnosed with severe AECOPD and admitted to the University Hospital of São Carlos from 2017 to 2019 were enrolled in this observational clinical study. Endothelial Function was assessed by brachial artery ultrasonography (M-Turbo, Sonosite, Bottle, WA, USA) and Flow Mediated Dilatation (FMD) technique in absolute (mm) and percentage values (%). Walking distance (6MWD) obtained by six-minute walk test was considered to characterize the exercise capacity. Pearson’s correlation analysis and linear regression model were applied and a significance level of 5%. There was a significant positive correlation between exercise capacity and endothelial function. Pearson correlation coefficient were 0.36 (p = 0.02) and 0.40 (p = 0.01) between 6MWD and FMD in mm and %, respectively. Linear regression model revealed 6MWD (p = 0.007), accounting for 15% of FMD (%) variance (R2 adjusted). FMD (%) = 2.11 + (0.0081*6MWD). Exercise capacity is associated with endothelial function in patients with severe AECOPD. FMD was found to be increasing with increasing walked distance. Further research is needed to provide evidence of effectiveness of rehabilitation on exercise capacity and endothelial function in these patients and its prognostic value.
format	article
author	Erika Zavaglia Kabbach Alessandro Domingues Heubel Cassia da Luz Goulart Valéria Amorim Pires Di Lorenzo Shane A. Phillips Audrey Borghi-Silva Renata Gonçalves Mendes
author_facet	Erika Zavaglia Kabbach Alessandro Domingues Heubel Cassia da Luz Goulart Valéria Amorim Pires Di Lorenzo Shane A. Phillips Audrey Borghi-Silva Renata Gonçalves Mendes
author_sort	Erika Zavaglia Kabbach
title	Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease
title_short	Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease
title_full	Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease
title_fullStr	Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease
title_full_unstemmed	Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease
title_sort	association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb229bdb28fc48748ff89e70042d7bf9
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Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease

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