Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development
Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad m...
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Nature Portfolio
2019
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oai:doaj.org-article:fb22d9e2478a422ebc121e8f033474f42021-12-02T15:35:47ZSingle-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development10.1038/s41467-019-08453-12041-1723https://doaj.org/article/fb22d9e2478a422ebc121e8f033474f42019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08453-1https://doaj.org/toc/2041-1723Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) to identify and characterize seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons.Katarína TiklováÅsa K. BjörklundLaura LahtiAlessandro FiorenzanoSara NolbrantLinda GillbergNikolaos VolakakisChika YokotaMarkus M. HilscherThomas HaulingFredrik HolmströmEliza JoodmardiMats NilssonMalin ParmarThomas PerlmannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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Science Q Katarína Tiklová Åsa K. Björklund Laura Lahti Alessandro Fiorenzano Sara Nolbrant Linda Gillberg Nikolaos Volakakis Chika Yokota Markus M. Hilscher Thomas Hauling Fredrik Holmström Eliza Joodmardi Mats Nilsson Malin Parmar Thomas Perlmann Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| description |
Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) to identify and characterize seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons. |
| format |
article |
| author |
Katarína Tiklová Åsa K. Björklund Laura Lahti Alessandro Fiorenzano Sara Nolbrant Linda Gillberg Nikolaos Volakakis Chika Yokota Markus M. Hilscher Thomas Hauling Fredrik Holmström Eliza Joodmardi Mats Nilsson Malin Parmar Thomas Perlmann |
| author_facet |
Katarína Tiklová Åsa K. Björklund Laura Lahti Alessandro Fiorenzano Sara Nolbrant Linda Gillberg Nikolaos Volakakis Chika Yokota Markus M. Hilscher Thomas Hauling Fredrik Holmström Eliza Joodmardi Mats Nilsson Malin Parmar Thomas Perlmann |
| author_sort |
Katarína Tiklová |
| title |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_short |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_full |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_fullStr |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_full_unstemmed |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_sort |
single-cell rna sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/fb22d9e2478a422ebc121e8f033474f4 |
| work_keys_str_mv |
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