Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice

Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet (HFD)-indu...

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Autores principales:	Eunkuk Park, Chang-Gun Lee, Hyoju Jeon, Hyesoo Jeong, Subin Yeo, Yoonjoong Yong, Seon-Yong Jeong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anti-obesity <i>Cornus officinalis</i> <i>Ribes fasciculatum</i> high-fat diet obese male mice Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/fb26044f8b42484786c6c9bd49a7b0cc
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spelling	oai:doaj.org-article:fb26044f8b42484786c6c9bd49a7b0cc2021-11-25T16:18:37ZAnti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice10.3390/ani111131872076-2615https://doaj.org/article/fb26044f8b42484786c6c9bd49a7b0cc2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3187https://doaj.org/toc/2076-2615Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.Eunkuk ParkChang-Gun LeeHyoju JeonHyesoo JeongSubin YeoYoonjoong YongSeon-Yong JeongMDPI AGarticleanti-obesity<i>Cornus officinalis</i><i>Ribes fasciculatum</i>high-fat dietobese male miceVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3187, p 3187 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-obesity <i>Cornus officinalis</i> <i>Ribes fasciculatum</i> high-fat diet obese male mice Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	anti-obesity <i>Cornus officinalis</i> <i>Ribes fasciculatum</i> high-fat diet obese male mice Veterinary medicine SF600-1100 Zoology QL1-991 Eunkuk Park Chang-Gun Lee Hyoju Jeon Hyesoo Jeong Subin Yeo Yoonjoong Yong Seon-Yong Jeong Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice
description	Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.
format	article
author	Eunkuk Park Chang-Gun Lee Hyoju Jeon Hyesoo Jeong Subin Yeo Yoonjoong Yong Seon-Yong Jeong
author_facet	Eunkuk Park Chang-Gun Lee Hyoju Jeon Hyesoo Jeong Subin Yeo Yoonjoong Yong Seon-Yong Jeong
author_sort	Eunkuk Park
title	Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice
title_short	Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice
title_full	Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice
title_fullStr	Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice
title_full_unstemmed	Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice
title_sort	anti-obesity effects of combined <i>cornus officinalis</i> and <i>ribes fasciculatum</i> extract in high-fat diet-induced obese male mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fb26044f8b42484786c6c9bd49a7b0cc
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Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice

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