Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors

The bacterial translocase channel anthrax toxin is composed of the protective antigen (PA) that forms a translocase channel and two cytotoxic enzymes: lethal factor (LF) and edema factor (EF), which go through the PA channel to enter host cells. Here the authors provide mechanistic insights into LF...

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Autores principales:	Nathan J. Hardenbrook, Shiheng Liu, Kang Zhou, Koyel Ghosal, Z. Hong Zhou, Bryan A. Krantz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb291522f6ab40dd9882fe0a6ae1849f
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spelling	oai:doaj.org-article:fb291522f6ab40dd9882fe0a6ae1849f2021-12-02T14:42:32ZAtomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors10.1038/s41467-020-14658-62041-1723https://doaj.org/article/fb291522f6ab40dd9882fe0a6ae1849f2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14658-6https://doaj.org/toc/2041-1723The bacterial translocase channel anthrax toxin is composed of the protective antigen (PA) that forms a translocase channel and two cytotoxic enzymes: lethal factor (LF) and edema factor (EF), which go through the PA channel to enter host cells. Here the authors provide mechanistic insights into LF and EF translocation by determining the cryo-EM structures of the anthrax toxin transmembrane channel protein in complex with LF and EF.Nathan J. HardenbrookShiheng LiuKang ZhouKoyel GhosalZ. Hong ZhouBryan A. KrantzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan J. Hardenbrook Shiheng Liu Kang Zhou Koyel Ghosal Z. Hong Zhou Bryan A. Krantz Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
description	The bacterial translocase channel anthrax toxin is composed of the protective antigen (PA) that forms a translocase channel and two cytotoxic enzymes: lethal factor (LF) and edema factor (EF), which go through the PA channel to enter host cells. Here the authors provide mechanistic insights into LF and EF translocation by determining the cryo-EM structures of the anthrax toxin transmembrane channel protein in complex with LF and EF.
format	article
author	Nathan J. Hardenbrook Shiheng Liu Kang Zhou Koyel Ghosal Z. Hong Zhou Bryan A. Krantz
author_facet	Nathan J. Hardenbrook Shiheng Liu Kang Zhou Koyel Ghosal Z. Hong Zhou Bryan A. Krantz
author_sort	Nathan J. Hardenbrook
title	Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
title_short	Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
title_full	Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
title_fullStr	Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
title_full_unstemmed	Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
title_sort	atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fb291522f6ab40dd9882fe0a6ae1849f
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Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors

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