Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells

Baoan Chen1*, Jian Cheng1*, Mingfang Shen1, Feng Gao1, Wenlin Xu2, et al1Department of Hematology;2Department of Hematology, The Affiliated People&rsquo;s Hospital, Jiangsu University, Zhenjiang, P.R China, et al&nbsp;*These authors have contributed equally to this work.Abstract: Apo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Baoan Chen, Jian Cheng, Mingfang Shen, Feng Gao, Wenlin Xu,&nbsp;et al&nbsp;
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fb324866867145c986ebc90dc88f043f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fb324866867145c986ebc90dc88f043f
record_format	dspace
spelling	oai:doaj.org-article:fb324866867145c986ebc90dc88f043f2021-12-02T04:21:18ZMagnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells1176-91141178-2013https://doaj.org/article/fb324866867145c986ebc90dc88f043f2009-03-01T00:00:00Zhttp://www.dovepress.com/magnetic-nanoparticle-of-fe3o4-and-5-bromotetrandrin-interact-synergis-a2975https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Baoan Chen1, Jian Cheng1, Mingfang Shen1, Feng Gao1, Wenlin Xu2, et al1Department of Hematology;2Department of Hematology, The Affiliated People&rsquo;s Hospital, Jiangsu University, Zhenjiang, P.R China, et al&nbsp;*These authors have contributed equally to this work.Abstract: Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe3O4 (MNP(Fe3O4)) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe3O4) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe3O4) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe3O4) and BrTet combination on CML.Keywords: K562/A02 leukemic cells, multidrug resistance, magnetic nanoparticle of Fe3O4, 5-bromotetrandrine, apoptosis, P53, caspase-3 Baoan ChenJian ChengMingfang ShenFeng GaoWenlin Xu,&nbsp;et al&nbsp;Dove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 65-71 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Baoan Chen Jian Cheng Mingfang Shen Feng Gao Wenlin Xu,&nbsp;et al&nbsp; Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
description	Baoan Chen1, Jian Cheng1, Mingfang Shen1, Feng Gao1, Wenlin Xu2, et al1Department of Hematology;2Department of Hematology, The Affiliated People&rsquo;s Hospital, Jiangsu University, Zhenjiang, P.R China, et al&nbsp;*These authors have contributed equally to this work.Abstract: Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe3O4 (MNP(Fe3O4)) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe3O4) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe3O4) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe3O4) and BrTet combination on CML.Keywords: K562/A02 leukemic cells, multidrug resistance, magnetic nanoparticle of Fe3O4, 5-bromotetrandrine, apoptosis, P53, caspase-3
format	article
author	Baoan Chen Jian Cheng Mingfang Shen Feng Gao Wenlin Xu,&nbsp;et al&nbsp;
author_facet	Baoan Chen Jian Cheng Mingfang Shen Feng Gao Wenlin Xu,&nbsp;et al&nbsp;
author_sort	Baoan Chen
title	Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_short	Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_full	Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_fullStr	Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_full_unstemmed	Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
title_sort	magnetic nanoparticle of fe3o4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/fb324866867145c986ebc90dc88f043f
work_keys_str_mv	AT baoanchen magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT jiancheng magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT mingfangshen magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT fenggao magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells AT wenlinxuampnbspetalampnbsp magneticnanoparticleoffe3o4and5bromotetrandrininteractsynergisticallytoinduceapoptosisbydaunorubicininleukemiacells
_version_	1718401346163441664

Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells

Ejemplares similares