Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

NLRP1 and CARD8 are two recently described sensor proteins for the human inflammasome complex. Here, the authors present the cryo-EM CARD filament structures of the NLRP1 and CARD8 activating domains, which reveal how NLRP1 and CARD8 discriminate between ASC and pro-caspase-1. They further propose a...

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Autores principales:	Qin Gong, Kim Robinson, Chenrui Xu, Phuong Thao Huynh, Kelvin Han Chung Chong, Eddie Yong Jun Tan, Jiawen Zhang, Zhao Zhi Boo, Daniel Eng Thiam Teo, Kenneth Lay, Yaming Zhang, John Soon Yew Lim, Wah Ing Goh, Graham Wright, Franklin L. Zhong, Bruno Reversade, Bin Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb33e8feb690411b8e3bbd80f9119b57
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spelling	oai:doaj.org-article:fb33e8feb690411b8e3bbd80f9119b572021-12-02T15:16:23ZStructural basis for distinct inflammasome complex assembly by human NLRP1 and CARD810.1038/s41467-020-20319-52041-1723https://doaj.org/article/fb33e8feb690411b8e3bbd80f9119b572021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20319-5https://doaj.org/toc/2041-1723NLRP1 and CARD8 are two recently described sensor proteins for the human inflammasome complex. Here, the authors present the cryo-EM CARD filament structures of the NLRP1 and CARD8 activating domains, which reveal how NLRP1 and CARD8 discriminate between ASC and pro-caspase-1. They further propose a two-step model for NLRP1 activation.Qin GongKim RobinsonChenrui XuPhuong Thao HuynhKelvin Han Chung ChongEddie Yong Jun TanJiawen ZhangZhao Zhi BooDaniel Eng Thiam TeoKenneth LayYaming ZhangJohn Soon Yew LimWah Ing GohGraham WrightFranklin L. ZhongBruno ReversadeBin WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qin Gong Kim Robinson Chenrui Xu Phuong Thao Huynh Kelvin Han Chung Chong Eddie Yong Jun Tan Jiawen Zhang Zhao Zhi Boo Daniel Eng Thiam Teo Kenneth Lay Yaming Zhang John Soon Yew Lim Wah Ing Goh Graham Wright Franklin L. Zhong Bruno Reversade Bin Wu Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
description	NLRP1 and CARD8 are two recently described sensor proteins for the human inflammasome complex. Here, the authors present the cryo-EM CARD filament structures of the NLRP1 and CARD8 activating domains, which reveal how NLRP1 and CARD8 discriminate between ASC and pro-caspase-1. They further propose a two-step model for NLRP1 activation.
format	article
author	Qin Gong Kim Robinson Chenrui Xu Phuong Thao Huynh Kelvin Han Chung Chong Eddie Yong Jun Tan Jiawen Zhang Zhao Zhi Boo Daniel Eng Thiam Teo Kenneth Lay Yaming Zhang John Soon Yew Lim Wah Ing Goh Graham Wright Franklin L. Zhong Bruno Reversade Bin Wu
author_facet	Qin Gong Kim Robinson Chenrui Xu Phuong Thao Huynh Kelvin Han Chung Chong Eddie Yong Jun Tan Jiawen Zhang Zhao Zhi Boo Daniel Eng Thiam Teo Kenneth Lay Yaming Zhang John Soon Yew Lim Wah Ing Goh Graham Wright Franklin L. Zhong Bruno Reversade Bin Wu
author_sort	Qin Gong
title	Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
title_short	Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
title_full	Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
title_fullStr	Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
title_full_unstemmed	Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
title_sort	structural basis for distinct inflammasome complex assembly by human nlrp1 and card8
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb33e8feb690411b8e3bbd80f9119b57
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Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

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