Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin and colleagues perform structure-guided modifications of the compound uronic isofagomaine in order to engineer a highly specific and potent inhibitor of gut bacterial β-glucuronidases (GUSs). The authors present eight crystal structures and demonstrate in v...

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Autores principales: Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin, Lun-Fu Yeh, Wei-Che Hsieh, Shijay Gao, Pierre-Alain Burnouf, Bing-Mae Chen, Tung-Ju Hsieh, Punsaldulam Dashnyam, Yen-Hsi Kuo, Zhijay Tu, Steve R. Roffler, Chun-Hung Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/fb39bb5584a546bea3aca76fb3fd4c02
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