Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.

Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.

<h4>Background</h4>The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes ("enhanceosomes") that upregulate expression of select genes within the inflammatory cascade during critica...

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Autores principales: Rebecca M Baron, Silvia Lopez-Guzman, Dario F Riascos, Alvaro A Macias, Matthew D Layne, Guiying Cheng, Cailin Harris, Su Wol Chung, Raymond Reeves, Ulrich H von Andrian, Mark A Perrella
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/fb4208f660984133b0e2ed0d972ca126
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