Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis

Insulin promotes lipogenesis but, on the other hand, insulin resistance is associated with increased lipogenesis in the liver. Here the authors show that Snail1 is upregulated by insulin and inhibits lipogenesis by repressing Fasn expression but insulin-mediated Snail1 upregulation is impaired durin...

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Autores principales:	Yan Liu, Lin Jiang, Chengxin Sun, Nicole Ireland, Yatrik M. Shah, Yong Liu, Liangyou Rui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb43cedf45f04c168de42b863bf71c45
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spelling	oai:doaj.org-article:fb43cedf45f04c168de42b863bf71c452021-12-02T17:31:58ZInsulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis10.1038/s41467-018-05309-y2041-1723https://doaj.org/article/fb43cedf45f04c168de42b863bf71c452018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05309-yhttps://doaj.org/toc/2041-1723Insulin promotes lipogenesis but, on the other hand, insulin resistance is associated with increased lipogenesis in the liver. Here the authors show that Snail1 is upregulated by insulin and inhibits lipogenesis by repressing Fasn expression but insulin-mediated Snail1 upregulation is impaired during obesity and insulin resistance.Yan LiuLin JiangChengxin SunNicole IrelandYatrik M. ShahYong LiuLiangyou RuiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Liu Lin Jiang Chengxin Sun Nicole Ireland Yatrik M. Shah Yong Liu Liangyou Rui Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
description	Insulin promotes lipogenesis but, on the other hand, insulin resistance is associated with increased lipogenesis in the liver. Here the authors show that Snail1 is upregulated by insulin and inhibits lipogenesis by repressing Fasn expression but insulin-mediated Snail1 upregulation is impaired during obesity and insulin resistance.
format	article
author	Yan Liu Lin Jiang Chengxin Sun Nicole Ireland Yatrik M. Shah Yong Liu Liangyou Rui
author_facet	Yan Liu Lin Jiang Chengxin Sun Nicole Ireland Yatrik M. Shah Yong Liu Liangyou Rui
author_sort	Yan Liu
title	Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
title_short	Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
title_full	Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
title_fullStr	Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
title_full_unstemmed	Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
title_sort	insulin/snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb43cedf45f04c168de42b863bf71c45
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_version_	1718380469091827712

Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis

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