Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus

The aim of this study was to investigate effect of Staphylococcus aureus on oxidative stress status (TAS, TOS, OSI), immune system (IL-1β, IL-6, TNF-α), and mineral (Mg, Fe, Zn, Cu, Na and Ca) concentrations in milk and serum of cows with mastitis. The cows were allocated to three groups according t...

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Autores principales:	Serdal KURT, Funda ESKI, Leyla MIS, Pinar AYVAZOGLU DEMIR
Formato:	article
Lenguaje:	EN
Publicado:	University of Kafkas 2021
Materias:	cytokine mastitis mineral substance oxidative stress staphylococcus aureus Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/fb44c9dad0f249e99724854a632e5613
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spelling	oai:doaj.org-article:fb44c9dad0f249e99724854a632e56132021-12-05T21:47:51ZEvaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus10.9775/kvfd.2021.262811300-60451309-2251https://doaj.org/article/fb44c9dad0f249e99724854a632e56132021-11-01T00:00:00Zhttp://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2863.pdfhttps://doaj.org/toc/1300-6045https://doaj.org/toc/1309-2251The aim of this study was to investigate effect of Staphylococcus aureus on oxidative stress status (TAS, TOS, OSI), immune system (IL-1β, IL-6, TNF-α), and mineral (Mg, Fe, Zn, Cu, Na and Ca) concentrations in milk and serum of cows with mastitis. The cows were allocated to three groups according to mammary health status as follows: healthy (Group 1), clinical (Group 2) and subclinical mastitis cows (Group 3). IL-1β levels in serum and milk increased in Group 2 compared to Group 1 and Group 3 (P<0.001; P<0.05). Milk IL-6 level was greater in Group 3 and Group 2 than in Group 1 (P<0.01). Blood TNF-α (P<0.001), TOS and OSI levels (P<0.01) were higher in Group 2 than other groups. Milk TNF-α level increased and blood TAS level decreased in Group 2 compared to Group 1 (P<0.05). Milk TOS (P<0.01) and OSI (P<0.05) levels increased in Group 3 compared to Group 1. Blood and milk Mg levels increased in Group 1 (P<0.05) and Group 2 (P<0.001), respectively. Milk Fe (P<0.01) and Na levels were greater in Group 2 (P<0.001). Blood Zn level was lower in Group 2 compared to Group 3 (P<0.05). While blood Cu level decreased in Group 1 compared to other groups, milk Cu level decreased in Group 3 compared to other groups (P<0.001). In conclusion, S. aureus had significant effects on oxidative stress, cytokine and mineral levels in milk and blood serum of cows with clinical and subclinical mastitis. However, since there were specific changes only in milk OSI and IL-6 levels according to other parameters, it is thought that milk IL-6 and OSI levels may be a diagnostic tool in the detection of subclinical mastitis.Serdal KURTFunda ESKI Leyla MISPinar AYVAZOGLU DEMIRUniversity of Kafkasarticlecytokinemastitismineral substanceoxidative stressstaphylococcus aureusVeterinary medicineSF600-1100ENKafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 6, Pp 755-762 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytokine mastitis mineral substance oxidative stress staphylococcus aureus Veterinary medicine SF600-1100
spellingShingle	cytokine mastitis mineral substance oxidative stress staphylococcus aureus Veterinary medicine SF600-1100 Serdal KURT Funda ESKI Leyla MIS Pinar AYVAZOGLU DEMIR Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus
description	The aim of this study was to investigate effect of Staphylococcus aureus on oxidative stress status (TAS, TOS, OSI), immune system (IL-1β, IL-6, TNF-α), and mineral (Mg, Fe, Zn, Cu, Na and Ca) concentrations in milk and serum of cows with mastitis. The cows were allocated to three groups according to mammary health status as follows: healthy (Group 1), clinical (Group 2) and subclinical mastitis cows (Group 3). IL-1β levels in serum and milk increased in Group 2 compared to Group 1 and Group 3 (P<0.001; P<0.05). Milk IL-6 level was greater in Group 3 and Group 2 than in Group 1 (P<0.01). Blood TNF-α (P<0.001), TOS and OSI levels (P<0.01) were higher in Group 2 than other groups. Milk TNF-α level increased and blood TAS level decreased in Group 2 compared to Group 1 (P<0.05). Milk TOS (P<0.01) and OSI (P<0.05) levels increased in Group 3 compared to Group 1. Blood and milk Mg levels increased in Group 1 (P<0.05) and Group 2 (P<0.001), respectively. Milk Fe (P<0.01) and Na levels were greater in Group 2 (P<0.001). Blood Zn level was lower in Group 2 compared to Group 3 (P<0.05). While blood Cu level decreased in Group 1 compared to other groups, milk Cu level decreased in Group 3 compared to other groups (P<0.001). In conclusion, S. aureus had significant effects on oxidative stress, cytokine and mineral levels in milk and blood serum of cows with clinical and subclinical mastitis. However, since there were specific changes only in milk OSI and IL-6 levels according to other parameters, it is thought that milk IL-6 and OSI levels may be a diagnostic tool in the detection of subclinical mastitis.
format	article
author	Serdal KURT Funda ESKI Leyla MIS Pinar AYVAZOGLU DEMIR
author_facet	Serdal KURT Funda ESKI Leyla MIS Pinar AYVAZOGLU DEMIR
author_sort	Serdal KURT
title	Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus
title_short	Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus
title_full	Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus
title_fullStr	Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus
title_full_unstemmed	Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus
title_sort	evaluation of oxidative stress, immune system and mineral concentrations in milk and serum of cows with clinical and subclinical mastitis naturally infected by staphylococcus aureus
publisher	University of Kafkas
publishDate	2021
url	https://doaj.org/article/fb44c9dad0f249e99724854a632e5613
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Evaluation of Oxidative Stress, Immune System and Mineral Concentrations in Milk and Serum of Cows with Clinical and Subclinical Mastitis Naturally Infected by Staphylococcus aureus

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