Identification of the kinase STK25 as an upstream activator of LATS signaling

Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range of human cancers.

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Autores principales:	Sanghee Lim, Nicole Hermance, Tenny Mudianto, Hatim M. Mustaly, Ian Paolo Morelos Mauricio, Marc A. Vittoria, Ryan J. Quinton, Brian W. Howell, Hauke Cornils, Amity L. Manning, Neil J. Ganem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb44cfbe9f3a4df592b8189461124a06
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spelling	oai:doaj.org-article:fb44cfbe9f3a4df592b8189461124a062021-12-02T15:35:49ZIdentification of the kinase STK25 as an upstream activator of LATS signaling10.1038/s41467-019-09597-w2041-1723https://doaj.org/article/fb44cfbe9f3a4df592b8189461124a062019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09597-whttps://doaj.org/toc/2041-1723Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range of human cancers.Sanghee LimNicole HermanceTenny MudiantoHatim M. MustalyIan Paolo Morelos MauricioMarc A. VittoriaRyan J. QuintonBrian W. HowellHauke CornilsAmity L. ManningNeil J. GanemNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sanghee Lim Nicole Hermance Tenny Mudianto Hatim M. Mustaly Ian Paolo Morelos Mauricio Marc A. Vittoria Ryan J. Quinton Brian W. Howell Hauke Cornils Amity L. Manning Neil J. Ganem Identification of the kinase STK25 as an upstream activator of LATS signaling
description	Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range of human cancers.
format	article
author	Sanghee Lim Nicole Hermance Tenny Mudianto Hatim M. Mustaly Ian Paolo Morelos Mauricio Marc A. Vittoria Ryan J. Quinton Brian W. Howell Hauke Cornils Amity L. Manning Neil J. Ganem
author_facet	Sanghee Lim Nicole Hermance Tenny Mudianto Hatim M. Mustaly Ian Paolo Morelos Mauricio Marc A. Vittoria Ryan J. Quinton Brian W. Howell Hauke Cornils Amity L. Manning Neil J. Ganem
author_sort	Sanghee Lim
title	Identification of the kinase STK25 as an upstream activator of LATS signaling
title_short	Identification of the kinase STK25 as an upstream activator of LATS signaling
title_full	Identification of the kinase STK25 as an upstream activator of LATS signaling
title_fullStr	Identification of the kinase STK25 as an upstream activator of LATS signaling
title_full_unstemmed	Identification of the kinase STK25 as an upstream activator of LATS signaling
title_sort	identification of the kinase stk25 as an upstream activator of lats signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fb44cfbe9f3a4df592b8189461124a06
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Identification of the kinase STK25 as an upstream activator of LATS signaling

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