Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:fb44f30d36cd44489c416d57ce1aadce2021-12-01T16:58:06ZCase Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China2296-858X10.3389/fmed.2021.783646https://doaj.org/article/fb44f30d36cd44489c416d57ce1aadce2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.783646/fullhttps://doaj.org/toc/2296-858XThe pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain into Sichuan Province, China, on March 11, 2020. The infected male had a body temperature of 37.5°C, normal blood oxygen saturation levels, and a computed tomography (CT) examination showed that his lungs had no shadows. However, a throat swab from the subject tested positive for SARS-CoV-2 using qPCR assay. In this study, we conducted transcriptome sequencing on respiratory throat swabs from the subject and found that the dominant SARS-CoV-2 sequence (Gene Bank ID: MW301121) was a spike protein D614G mutant strain, which is currently popular throughout world. We downloaded and analyzed SARS-CoV-2 sequences collected from cases in China and Spain for comparison and tracing purposes. After March 11, 2020, the Chinese domestic clade was naturally divided into the imported SARS-CoV-2 D614G mutant strain and evolutionarily-related similar sequences and that of sequences collected in the original Wuhan area. The sequence reported in this study was located on a small branch, far from the evolution of Wuhan sequences. As expected, the identified sequence was closely related to the evolution of the SARS-CoV-2 D614G mutant strain circulating in Spain.Chao LiuChao LiuBin TangCan GaoCan GaoJianjun DengMin ShenChaolin LiZekun FuZhan GaoQi JiangHao ShiMiao HeHuaiwu JiangXu JiaXu JiaFrontiers Media S.A.articleSARS coronavirusvirus classificationBLAST algorithmbiostatistics and bioinformaticsclustal analysisMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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SARS coronavirus virus classification BLAST algorithm biostatistics and bioinformatics clustal analysis Medicine (General) R5-920 |
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SARS coronavirus virus classification BLAST algorithm biostatistics and bioinformatics clustal analysis Medicine (General) R5-920 Chao Liu Chao Liu Bin Tang Can Gao Can Gao Jianjun Deng Min Shen Chaolin Li Zekun Fu Zhan Gao Qi Jiang Hao Shi Miao He Huaiwu Jiang Xu Jia Xu Jia Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
| description |
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been basically under control in China since March 2020, but the import of domestic SARS-CoV-2 has begun to increase. This study reported the first case of asymptomatic SARS-CoV-2 infection imported from Spain into Sichuan Province, China, on March 11, 2020. The infected male had a body temperature of 37.5°C, normal blood oxygen saturation levels, and a computed tomography (CT) examination showed that his lungs had no shadows. However, a throat swab from the subject tested positive for SARS-CoV-2 using qPCR assay. In this study, we conducted transcriptome sequencing on respiratory throat swabs from the subject and found that the dominant SARS-CoV-2 sequence (Gene Bank ID: MW301121) was a spike protein D614G mutant strain, which is currently popular throughout world. We downloaded and analyzed SARS-CoV-2 sequences collected from cases in China and Spain for comparison and tracing purposes. After March 11, 2020, the Chinese domestic clade was naturally divided into the imported SARS-CoV-2 D614G mutant strain and evolutionarily-related similar sequences and that of sequences collected in the original Wuhan area. The sequence reported in this study was located on a small branch, far from the evolution of Wuhan sequences. As expected, the identified sequence was closely related to the evolution of the SARS-CoV-2 D614G mutant strain circulating in Spain. |
| format |
article |
| author |
Chao Liu Chao Liu Bin Tang Can Gao Can Gao Jianjun Deng Min Shen Chaolin Li Zekun Fu Zhan Gao Qi Jiang Hao Shi Miao He Huaiwu Jiang Xu Jia Xu Jia |
| author_facet |
Chao Liu Chao Liu Bin Tang Can Gao Can Gao Jianjun Deng Min Shen Chaolin Li Zekun Fu Zhan Gao Qi Jiang Hao Shi Miao He Huaiwu Jiang Xu Jia Xu Jia |
| author_sort |
Chao Liu |
| title |
Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
| title_short |
Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
| title_full |
Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
| title_fullStr |
Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
| title_full_unstemmed |
Case Report: Genomic Characteristics of the First Known Case of SARS-CoV-2 Imported From Spain to Sichuan, China |
| title_sort |
case report: genomic characteristics of the first known case of sars-cov-2 imported from spain to sichuan, china |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/fb44f30d36cd44489c416d57ce1aadce |
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