Glioblastoma signature in the DNA of blood-derived cells.

Current approach for the detection of cancer is based on identifying genetic mutations typical to tumor cells. This approach is effective only when cancer has already emerged, however, it might be in a stage too advanced for effective treatment. Cancer is caused by the continuous accumulation of mut...

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Autores principales:	Siddharth Jain, Bijan Mazaheri, Netanel Raviv, Jehoshua Bruck
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb46b06b05994c9e84f745127c91a4bb
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spelling	oai:doaj.org-article:fb46b06b05994c9e84f745127c91a4bb2021-12-02T20:14:47ZGlioblastoma signature in the DNA of blood-derived cells.1932-620310.1371/journal.pone.0256831https://doaj.org/article/fb46b06b05994c9e84f745127c91a4bb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256831https://doaj.org/toc/1932-6203Current approach for the detection of cancer is based on identifying genetic mutations typical to tumor cells. This approach is effective only when cancer has already emerged, however, it might be in a stage too advanced for effective treatment. Cancer is caused by the continuous accumulation of mutations; is it possible to measure the time-dependent information of mutation accumulation and predict the emergence of cancer? We hypothesize that the mutation history derived from the tandem repeat regions in blood-derived DNA carries information about the accumulation of the cancer driver mutations in other tissues. To validate our hypothesis, we computed the mutation histories from the tandem repeat regions in blood-derived exomic DNA of 3874 TCGA patients with different cancer types and found a statistically significant signal with specificity ranging from 66% to 93% differentiating Glioblastoma patients from other cancer patients. Our approach and findings offer a new direction for future cancer prediction and early cancer detection based on information derived from blood-derived DNA.Siddharth JainBijan MazaheriNetanel RavivJehoshua BruckPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256831 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siddharth Jain Bijan Mazaheri Netanel Raviv Jehoshua Bruck Glioblastoma signature in the DNA of blood-derived cells.
description	Current approach for the detection of cancer is based on identifying genetic mutations typical to tumor cells. This approach is effective only when cancer has already emerged, however, it might be in a stage too advanced for effective treatment. Cancer is caused by the continuous accumulation of mutations; is it possible to measure the time-dependent information of mutation accumulation and predict the emergence of cancer? We hypothesize that the mutation history derived from the tandem repeat regions in blood-derived DNA carries information about the accumulation of the cancer driver mutations in other tissues. To validate our hypothesis, we computed the mutation histories from the tandem repeat regions in blood-derived exomic DNA of 3874 TCGA patients with different cancer types and found a statistically significant signal with specificity ranging from 66% to 93% differentiating Glioblastoma patients from other cancer patients. Our approach and findings offer a new direction for future cancer prediction and early cancer detection based on information derived from blood-derived DNA.
format	article
author	Siddharth Jain Bijan Mazaheri Netanel Raviv Jehoshua Bruck
author_facet	Siddharth Jain Bijan Mazaheri Netanel Raviv Jehoshua Bruck
author_sort	Siddharth Jain
title	Glioblastoma signature in the DNA of blood-derived cells.
title_short	Glioblastoma signature in the DNA of blood-derived cells.
title_full	Glioblastoma signature in the DNA of blood-derived cells.
title_fullStr	Glioblastoma signature in the DNA of blood-derived cells.
title_full_unstemmed	Glioblastoma signature in the DNA of blood-derived cells.
title_sort	glioblastoma signature in the dna of blood-derived cells.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fb46b06b05994c9e84f745127c91a4bb
work_keys_str_mv	AT siddharthjain glioblastomasignatureinthednaofbloodderivedcells AT bijanmazaheri glioblastomasignatureinthednaofbloodderivedcells AT netanelraviv glioblastomasignatureinthednaofbloodderivedcells AT jehoshuabruck glioblastomasignatureinthednaofbloodderivedcells
_version_	1718374683201503232

Glioblastoma signature in the DNA of blood-derived cells.

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