SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a ma...
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Nature Portfolio
2021
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oai:doaj.org-article:fb48f36f0ee14f8194aa51fcf0be0cc62021-12-02T16:35:53ZSARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition10.1038/s41467-021-22166-42041-1723https://doaj.org/article/fb48f36f0ee14f8194aa51fcf0be0cc62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22166-4https://doaj.org/toc/2041-1723The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a master metabolic regulator, suppresses viral replication.Peter J. MullenGustavo GarciaArunima PurkayasthaNedas MatulionisErnst W. SchmidMilica MomcilovicChandani SenJustin LangermanArunachalam RamaiahDavid B. ShackelfordRobert DamoiseauxSamuel W. FrenchKathrin PlathBrigitte N. GompertsVaithilingaraja ArumugaswamiHeather R. ChristofkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Peter J. Mullen Gustavo Garcia Arunima Purkayastha Nedas Matulionis Ernst W. Schmid Milica Momcilovic Chandani Sen Justin Langerman Arunachalam Ramaiah David B. Shackelford Robert Damoiseaux Samuel W. French Kathrin Plath Brigitte N. Gomperts Vaithilingaraja Arumugaswami Heather R. Christofk SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| description |
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a master metabolic regulator, suppresses viral replication. |
| format |
article |
| author |
Peter J. Mullen Gustavo Garcia Arunima Purkayastha Nedas Matulionis Ernst W. Schmid Milica Momcilovic Chandani Sen Justin Langerman Arunachalam Ramaiah David B. Shackelford Robert Damoiseaux Samuel W. French Kathrin Plath Brigitte N. Gomperts Vaithilingaraja Arumugaswami Heather R. Christofk |
| author_facet |
Peter J. Mullen Gustavo Garcia Arunima Purkayastha Nedas Matulionis Ernst W. Schmid Milica Momcilovic Chandani Sen Justin Langerman Arunachalam Ramaiah David B. Shackelford Robert Damoiseaux Samuel W. French Kathrin Plath Brigitte N. Gomperts Vaithilingaraja Arumugaswami Heather R. Christofk |
| author_sort |
Peter J. Mullen |
| title |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_short |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_full |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_fullStr |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_full_unstemmed |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_sort |
sars-cov-2 infection rewires host cell metabolism and is potentially susceptible to mtorc1 inhibition |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fb48f36f0ee14f8194aa51fcf0be0cc6 |
| work_keys_str_mv |
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| _version_ |
1718383731259998208 |