A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.

<h4>Introduction</h4>Retained radioactivity of 131I after ablation therapy largely differs in each patient according to factors including the amount of remnant thyroid tissue, renal function, and use of recombinant human thyroid-stimulating hormone. To reduce unnecessary restriction of p...

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Autores principales:	Sangwon Han, Soyoung Jin, Seon Hee Yoo, Hyo Sang Lee, Suk Hyun Lee, Min Ji Jeon, Jin-Sook Ryu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb4b0ad5bd5041d6acf047e745ae80c8
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spelling	oai:doaj.org-article:fb4b0ad5bd5041d6acf047e745ae80c82021-11-25T05:54:14ZA practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.1932-620310.1371/journal.pone.0251627https://doaj.org/article/fb4b0ad5bd5041d6acf047e745ae80c82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251627https://doaj.org/toc/1932-6203<h4>Introduction</h4>Retained radioactivity of 131I after ablation therapy largely differs in each patient according to factors including the amount of remnant thyroid tissue, renal function, and use of recombinant human thyroid-stimulating hormone. To reduce unnecessary restriction of patient's daily life after inpatient 131I ablation therapy, we propose a practical individualized method for radiation precaution based on dose rate at release time.<h4>Methods</h4>We evaluated 215 patients with differentiated thyroid cancer who underwent inpatient 131I ablation therapy following total thyroidectomy. Effective dose equivalent rates at 1-m distance were measured upon release (EDRR) on day 2 and during delayed whole-body scan (EDRD) visits on day 6‒8 after 131I administration. The biexponential model was designed to estimate total effective dose equivalent to others. To assess conservativeness of our model, EDRD estimated by our model was compared with measured EDRD. EDRR-based periods of precaution not to receiving 1 mSv of radiation exposure were estimated and compared with those based on administered radioactivities on American Thyroid Association (ATA) recommendations.<h4>Results</h4>The EDRR ranged from 1.0-48.9 μSv/hr. The measured EDRD were equal to or lower than estimated EDRD in all patients, except for one, indicating that our model is sufficiently conservative. According to our model, no subjects needed additional daytime restriction after release. The maximum permissible times for public transportation use were longer in all patients compared with those based on administered radioactivities. Nighttime restriction periods were significantly shorter than those based on administered radioactivity; median periods requiring sleeping apart were 0 (range, 0‒5), 4 (range, 1‒14), and 3 (range, 2‒13) days after release in patients treated with radioactivity doses of 2.96, 5.50, and 7.40 GBq, respectively, needing 8, 16, and 19 additional days, respectively, based on administered radioactivity.<h4>Conclusions</h4>Radiation safety instructions using proposed method based on EDRR of individual patient could safely reduce the burden of radiation precaution.Sangwon HanSoyoung JinSeon Hee YooHyo Sang LeeSuk Hyun LeeMin Ji JeonJin-Sook RyuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251627 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sangwon Han Soyoung Jin Seon Hee Yoo Hyo Sang Lee Suk Hyun Lee Min Ji Jeon Jin-Sook Ryu A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.
description	<h4>Introduction</h4>Retained radioactivity of 131I after ablation therapy largely differs in each patient according to factors including the amount of remnant thyroid tissue, renal function, and use of recombinant human thyroid-stimulating hormone. To reduce unnecessary restriction of patient's daily life after inpatient 131I ablation therapy, we propose a practical individualized method for radiation precaution based on dose rate at release time.<h4>Methods</h4>We evaluated 215 patients with differentiated thyroid cancer who underwent inpatient 131I ablation therapy following total thyroidectomy. Effective dose equivalent rates at 1-m distance were measured upon release (EDRR) on day 2 and during delayed whole-body scan (EDRD) visits on day 6‒8 after 131I administration. The biexponential model was designed to estimate total effective dose equivalent to others. To assess conservativeness of our model, EDRD estimated by our model was compared with measured EDRD. EDRR-based periods of precaution not to receiving 1 mSv of radiation exposure were estimated and compared with those based on administered radioactivities on American Thyroid Association (ATA) recommendations.<h4>Results</h4>The EDRR ranged from 1.0-48.9 μSv/hr. The measured EDRD were equal to or lower than estimated EDRD in all patients, except for one, indicating that our model is sufficiently conservative. According to our model, no subjects needed additional daytime restriction after release. The maximum permissible times for public transportation use were longer in all patients compared with those based on administered radioactivities. Nighttime restriction periods were significantly shorter than those based on administered radioactivity; median periods requiring sleeping apart were 0 (range, 0‒5), 4 (range, 1‒14), and 3 (range, 2‒13) days after release in patients treated with radioactivity doses of 2.96, 5.50, and 7.40 GBq, respectively, needing 8, 16, and 19 additional days, respectively, based on administered radioactivity.<h4>Conclusions</h4>Radiation safety instructions using proposed method based on EDRR of individual patient could safely reduce the burden of radiation precaution.
format	article
author	Sangwon Han Soyoung Jin Seon Hee Yoo Hyo Sang Lee Suk Hyun Lee Min Ji Jeon Jin-Sook Ryu
author_facet	Sangwon Han Soyoung Jin Seon Hee Yoo Hyo Sang Lee Suk Hyun Lee Min Ji Jeon Jin-Sook Ryu
author_sort	Sangwon Han
title	A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.
title_short	A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.
title_full	A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.
title_fullStr	A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.
title_full_unstemmed	A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.
title_sort	practical individualized radiation precaution based on the dose rate at release time after inpatient 131i ablation therapy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fb4b0ad5bd5041d6acf047e745ae80c8
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A practical individualized radiation precaution based on the dose rate at release time after inpatient 131I ablation therapy.

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