Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination

Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination

Microglia are important for brain homeostasis and plasticity. The mechanisms underlying microglia-neuron interactions are still unclear. Here, the authors show that microglia preferentially interact with the nodes of Ranvier along axons. This interaction is modulated by neuronal activity and contrib...

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Autores principales: R. Ronzano, T. Roux, M. Thetiot, M. S. Aigrot, L. Richard, F. X. Lejeune, E. Mazuir, J. M. Vallat, C. Lubetzki, A. Desmazières
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fb4d5db5626f437294c686841cb40c71
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spelling oai:doaj.org-article:fb4d5db5626f437294c686841cb40c712021-12-02T15:26:52ZMicroglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination10.1038/s41467-021-25486-72041-1723https://doaj.org/article/fb4d5db5626f437294c686841cb40c712021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25486-7https://doaj.org/toc/2041-1723Microglia are important for brain homeostasis and plasticity. The mechanisms underlying microglia-neuron interactions are still unclear. Here, the authors show that microglia preferentially interact with the nodes of Ranvier along axons. This interaction is modulated by neuronal activity and contributes to remyelination in mice.R. RonzanoT. RouxM. ThetiotM. S. AigrotL. RichardF. X. LejeuneE. MazuirJ. M. VallatC. LubetzkiA. DesmazièresNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
R. Ronzano
T. Roux
M. Thetiot
M. S. Aigrot
L. Richard
F. X. Lejeune
E. Mazuir
J. M. Vallat
C. Lubetzki
A. Desmazières
Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
description Microglia are important for brain homeostasis and plasticity. The mechanisms underlying microglia-neuron interactions are still unclear. Here, the authors show that microglia preferentially interact with the nodes of Ranvier along axons. This interaction is modulated by neuronal activity and contributes to remyelination in mice.
format article
author R. Ronzano
T. Roux
M. Thetiot
M. S. Aigrot
L. Richard
F. X. Lejeune
E. Mazuir
J. M. Vallat
C. Lubetzki
A. Desmazières
author_facet R. Ronzano
T. Roux
M. Thetiot
M. S. Aigrot
L. Richard
F. X. Lejeune
E. Mazuir
J. M. Vallat
C. Lubetzki
A. Desmazières
author_sort R. Ronzano
title Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
title_short Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
title_full Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
title_fullStr Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
title_full_unstemmed Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
title_sort microglia-neuron interaction at nodes of ranvier depends on neuronal activity through potassium release and contributes to remyelination
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fb4d5db5626f437294c686841cb40c71
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