The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country

Abstract Background Accurate diagnosis of lung lesions appearing on computed tomographic (CT) imaging in children with solid organ malignancies can be difficult. Therefore, this study aimed to determine, in a developing country setting, (1) the utility of thoracoscopic lung biopsy for assessment of...

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Autores principales:	Mark Wagener, Nasheeta Peer, Mahomed Hoosen Sheik-Gafoor
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Thoracoscopic lung biopsy Video-assisted thoracoscopic surgery (VATS) Solid organ malignancy Children Nephroblastoma Lung metastases Pediatrics RJ1-570 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/fb4d7722ada84bf5ac681c974f02f1f2
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spelling	oai:doaj.org-article:fb4d7722ada84bf5ac681c974f02f1f22021-11-14T12:24:41ZThe role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country10.1186/s43159-021-00123-62090-5394https://doaj.org/article/fb4d7722ada84bf5ac681c974f02f1f22021-11-01T00:00:00Zhttps://doi.org/10.1186/s43159-021-00123-6https://doaj.org/toc/2090-5394Abstract Background Accurate diagnosis of lung lesions appearing on computed tomographic (CT) imaging in children with solid organ malignancies can be difficult. Therefore, this study aimed to determine, in a developing country setting, (1) the utility of thoracoscopic lung biopsy for assessment of suspected lung metastases in solid organ malignancies, and (2) the pathology of biopsied lesions suspected to be malignancies. The electronic records of all patients with solid organ malignancies who underwent thoracoscopic lung biopsies for suspected metastases at a tertiary hospital in South Africa between January 2012 and December 2017 were analysed retrospectively. Results A total of 29 thoracoscopic biopsies were taken from 25 patients. In eight biopsies (27.6%), viable metastatic tumour was identified; in one, a completely necrotic tumour was found. Seven patients (28.0%) were found to have infective aetiologies which required alternative therapies: of these, three patients had tuberculosis; three had bronchopneumonia and one had a fungal lung infection. Other findings included haemorrhagic infarction (n = 1); non-specific fibrosis (n = 1) and reactive lymph node (n = 1). In ten biopsies (34.5%), no lesion was found on thoracoscopy. Conclusions Thoracoscopy was found to improve the management of children with solid organ malignancies and suspected metastases. Thoracoscopy enabled many patients to avoid additional chemotherapy and radiotherapy and its negative consequences and enabled therapy for specific benign pathologies including infections.Mark WagenerNasheeta PeerMahomed Hoosen Sheik-GafoorSpringerOpenarticleThoracoscopic lung biopsyVideo-assisted thoracoscopic surgery (VATS)Solid organ malignancyChildrenNephroblastomaLung metastasesPediatricsRJ1-570SurgeryRD1-811ENAnnals of Pediatric Surgery, Vol 17, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Thoracoscopic lung biopsy Video-assisted thoracoscopic surgery (VATS) Solid organ malignancy Children Nephroblastoma Lung metastases Pediatrics RJ1-570 Surgery RD1-811
spellingShingle	Thoracoscopic lung biopsy Video-assisted thoracoscopic surgery (VATS) Solid organ malignancy Children Nephroblastoma Lung metastases Pediatrics RJ1-570 Surgery RD1-811 Mark Wagener Nasheeta Peer Mahomed Hoosen Sheik-Gafoor The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country
description	Abstract Background Accurate diagnosis of lung lesions appearing on computed tomographic (CT) imaging in children with solid organ malignancies can be difficult. Therefore, this study aimed to determine, in a developing country setting, (1) the utility of thoracoscopic lung biopsy for assessment of suspected lung metastases in solid organ malignancies, and (2) the pathology of biopsied lesions suspected to be malignancies. The electronic records of all patients with solid organ malignancies who underwent thoracoscopic lung biopsies for suspected metastases at a tertiary hospital in South Africa between January 2012 and December 2017 were analysed retrospectively. Results A total of 29 thoracoscopic biopsies were taken from 25 patients. In eight biopsies (27.6%), viable metastatic tumour was identified; in one, a completely necrotic tumour was found. Seven patients (28.0%) were found to have infective aetiologies which required alternative therapies: of these, three patients had tuberculosis; three had bronchopneumonia and one had a fungal lung infection. Other findings included haemorrhagic infarction (n = 1); non-specific fibrosis (n = 1) and reactive lymph node (n = 1). In ten biopsies (34.5%), no lesion was found on thoracoscopy. Conclusions Thoracoscopy was found to improve the management of children with solid organ malignancies and suspected metastases. Thoracoscopy enabled many patients to avoid additional chemotherapy and radiotherapy and its negative consequences and enabled therapy for specific benign pathologies including infections.
format	article
author	Mark Wagener Nasheeta Peer Mahomed Hoosen Sheik-Gafoor
author_facet	Mark Wagener Nasheeta Peer Mahomed Hoosen Sheik-Gafoor
author_sort	Mark Wagener
title	The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country
title_short	The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country
title_full	The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country
title_fullStr	The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country
title_full_unstemmed	The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country
title_sort	role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/fb4d7722ada84bf5ac681c974f02f1f2
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The role of thoracoscopic lung biopsy in the management of children with solid organ malignancies and suspected lung metastases in a developing country

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