CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Overexpression of SNAIL confers tumour cells with cancer stem-like characteristics associated with tumour progression. Here the authors show that inhibition of CDK4/6 blocks tumour metastasis in triple negative breast cancer by targeting DUB3 which in turns deubiquitinates and stabilises SNAIL1.

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Autores principales:	Tongzheng Liu, Jia Yu, Min Deng, Yujiao Yin, Haoxing Zhang, Kuntian Luo, Bo Qin, Yunhui Li, Chenming Wu, Tao Ren, Yang Han, Peng Yin, JungJin Kim, SeungBaek Lee, Jing Lin, Lizhi Zhang, Jun Zhang, Somaira Nowsheen, Liewei Wang, Judy Boughey, Matthew P. Goetz, Jian Yuan, Zhenkun Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb4ebddfe07343f3a7aebc9d0883b068
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spelling	oai:doaj.org-article:fb4ebddfe07343f3a7aebc9d0883b0682021-12-02T14:42:41ZCDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL110.1038/ncomms139232041-1723https://doaj.org/article/fb4ebddfe07343f3a7aebc9d0883b0682017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13923https://doaj.org/toc/2041-1723Overexpression of SNAIL confers tumour cells with cancer stem-like characteristics associated with tumour progression. Here the authors show that inhibition of CDK4/6 blocks tumour metastasis in triple negative breast cancer by targeting DUB3 which in turns deubiquitinates and stabilises SNAIL1.Tongzheng LiuJia YuMin DengYujiao YinHaoxing ZhangKuntian LuoBo QinYunhui LiChenming WuTao RenYang HanPeng YinJungJin KimSeungBaek LeeJing LinLizhi ZhangJun ZhangSomaira NowsheenLiewei WangJudy BougheyMatthew P. GoetzJian YuanZhenkun LouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tongzheng Liu Jia Yu Min Deng Yujiao Yin Haoxing Zhang Kuntian Luo Bo Qin Yunhui Li Chenming Wu Tao Ren Yang Han Peng Yin JungJin Kim SeungBaek Lee Jing Lin Lizhi Zhang Jun Zhang Somaira Nowsheen Liewei Wang Judy Boughey Matthew P. Goetz Jian Yuan Zhenkun Lou CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
description	Overexpression of SNAIL confers tumour cells with cancer stem-like characteristics associated with tumour progression. Here the authors show that inhibition of CDK4/6 blocks tumour metastasis in triple negative breast cancer by targeting DUB3 which in turns deubiquitinates and stabilises SNAIL1.
format	article
author	Tongzheng Liu Jia Yu Min Deng Yujiao Yin Haoxing Zhang Kuntian Luo Bo Qin Yunhui Li Chenming Wu Tao Ren Yang Han Peng Yin JungJin Kim SeungBaek Lee Jing Lin Lizhi Zhang Jun Zhang Somaira Nowsheen Liewei Wang Judy Boughey Matthew P. Goetz Jian Yuan Zhenkun Lou
author_facet	Tongzheng Liu Jia Yu Min Deng Yujiao Yin Haoxing Zhang Kuntian Luo Bo Qin Yunhui Li Chenming Wu Tao Ren Yang Han Peng Yin JungJin Kim SeungBaek Lee Jing Lin Lizhi Zhang Jun Zhang Somaira Nowsheen Liewei Wang Judy Boughey Matthew P. Goetz Jian Yuan Zhenkun Lou
author_sort	Tongzheng Liu
title	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
title_short	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
title_full	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
title_fullStr	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
title_full_unstemmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1
title_sort	cdk4/6-dependent activation of dub3 regulates cancer metastasis through snail1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fb4ebddfe07343f3a7aebc9d0883b068
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CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

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