Molecular mechanisms of detection and discrimination of dynamic signals

Abstract Many molecules decode not only the concentration of cellular signals, but also their temporal dynamics. However, little is known about the mechanisms that underlie the detection and discrimination of dynamic signals. We used computational modelling of the interaction of a ligand with multip...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	G. Antunes, A. C. Roque, F. M. Simoes-de-Souza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fb4eef05566248a68fa7b3cd3074cb2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fb4eef05566248a68fa7b3cd3074cb2e
record_format	dspace
spelling	oai:doaj.org-article:fb4eef05566248a68fa7b3cd3074cb2e2021-12-02T15:09:12ZMolecular mechanisms of detection and discrimination of dynamic signals10.1038/s41598-018-20842-y2045-2322https://doaj.org/article/fb4eef05566248a68fa7b3cd3074cb2e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20842-yhttps://doaj.org/toc/2045-2322Abstract Many molecules decode not only the concentration of cellular signals, but also their temporal dynamics. However, little is known about the mechanisms that underlie the detection and discrimination of dynamic signals. We used computational modelling of the interaction of a ligand with multiple targets to investigate how kinetic and thermodynamic parameters regulate their capabilities to respond to dynamic signals. Our results demonstrated that the detection and discrimination of temporal features of signal inputs occur for reactions proceeding outside mass-action equilibrium. For these reactions, thermodynamic parameters such as affinity do not predict their outcomes. Additionally, we showed that, at non-equilibrium, the association rate constants determine the amount of product formed in reversible reactions. In contrast, the dissociation rate constants regulate the time interval required for reversible reactions to achieve equilibrium and, consequently, control their ability to detect and discriminate dynamic features of cellular signals.G. AntunesA. C. RoqueF. M. Simoes-de-SouzaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q G. Antunes A. C. Roque F. M. Simoes-de-Souza Molecular mechanisms of detection and discrimination of dynamic signals
description	Abstract Many molecules decode not only the concentration of cellular signals, but also their temporal dynamics. However, little is known about the mechanisms that underlie the detection and discrimination of dynamic signals. We used computational modelling of the interaction of a ligand with multiple targets to investigate how kinetic and thermodynamic parameters regulate their capabilities to respond to dynamic signals. Our results demonstrated that the detection and discrimination of temporal features of signal inputs occur for reactions proceeding outside mass-action equilibrium. For these reactions, thermodynamic parameters such as affinity do not predict their outcomes. Additionally, we showed that, at non-equilibrium, the association rate constants determine the amount of product formed in reversible reactions. In contrast, the dissociation rate constants regulate the time interval required for reversible reactions to achieve equilibrium and, consequently, control their ability to detect and discriminate dynamic features of cellular signals.
format	article
author	G. Antunes A. C. Roque F. M. Simoes-de-Souza
author_facet	G. Antunes A. C. Roque F. M. Simoes-de-Souza
author_sort	G. Antunes
title	Molecular mechanisms of detection and discrimination of dynamic signals
title_short	Molecular mechanisms of detection and discrimination of dynamic signals
title_full	Molecular mechanisms of detection and discrimination of dynamic signals
title_fullStr	Molecular mechanisms of detection and discrimination of dynamic signals
title_full_unstemmed	Molecular mechanisms of detection and discrimination of dynamic signals
title_sort	molecular mechanisms of detection and discrimination of dynamic signals
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fb4eef05566248a68fa7b3cd3074cb2e
work_keys_str_mv	AT gantunes molecularmechanismsofdetectionanddiscriminationofdynamicsignals AT acroque molecularmechanismsofdetectionanddiscriminationofdynamicsignals AT fmsimoesdesouza molecularmechanismsofdetectionanddiscriminationofdynamicsignals
_version_	1718387915745132544

Molecular mechanisms of detection and discrimination of dynamic signals

Ejemplares similares