Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients

ABSTRACT Cryptococcus spp. are important fungal pathogens that represent a major cause of morbidity and mortality in both immunocompetent and immunodeficient patients. Although cryptococcal disease is one of the major causes of death in HIV-infected patients, especially in sub-Saharan Africa, not al...

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Autor principal:	Mihai G. Netea
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/fb4f9e09f5f440db8bfced48faf72154
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spelling	oai:doaj.org-article:fb4f9e09f5f440db8bfced48faf721542021-11-15T15:42:48ZToward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients10.1128/mBio.00798-132150-7511https://doaj.org/article/fb4f9e09f5f440db8bfced48faf721542013-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00798-13https://doaj.org/toc/2150-7511ABSTRACT Cryptococcus spp. are important fungal pathogens that represent a major cause of morbidity and mortality in both immunocompetent and immunodeficient patients. Although cryptococcal disease is one of the major causes of death in HIV-infected patients, especially in sub-Saharan Africa, not all patients at risk with low CD4 counts develop the disease. It has been thus hypothesized that host genetic variation may represent an important susceptibility risk factor for this infection. In their recent study in mBio, Rohatgi et al. [S. Rohatgi et al., mBio 4(5):e00573-13, 2013, doi:10.1128/mBio.00573-13] present an important piece of evidence to support this hypothesis, by demonstrating that the FCGR3A 158 F/V polymorphism has an important impact on susceptibility to cryptococcal disease in HIV-infected patients. The authors present both genetic evidence and immunological validation for the hypothesis that humoral immunity in general and FCGR3A-mediated uptake and antibody-dependent cellular cytotoxicity (ADCC) in particular play important roles in the pathogenesis of Cryptococcus infection. Their discovery that the 158V allele of this polymorphism can increase the risk of Cryptococcus infections up to 20-fold in homozygous individuals opens the possibility for risk stratification and personalized treatment of HIV-infected patients.Mihai G. NeteaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 5 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Mihai G. Netea Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients
description	ABSTRACT Cryptococcus spp. are important fungal pathogens that represent a major cause of morbidity and mortality in both immunocompetent and immunodeficient patients. Although cryptococcal disease is one of the major causes of death in HIV-infected patients, especially in sub-Saharan Africa, not all patients at risk with low CD4 counts develop the disease. It has been thus hypothesized that host genetic variation may represent an important susceptibility risk factor for this infection. In their recent study in mBio, Rohatgi et al. [S. Rohatgi et al., mBio 4(5):e00573-13, 2013, doi:10.1128/mBio.00573-13] present an important piece of evidence to support this hypothesis, by demonstrating that the FCGR3A 158 F/V polymorphism has an important impact on susceptibility to cryptococcal disease in HIV-infected patients. The authors present both genetic evidence and immunological validation for the hypothesis that humoral immunity in general and FCGR3A-mediated uptake and antibody-dependent cellular cytotoxicity (ADCC) in particular play important roles in the pathogenesis of Cryptococcus infection. Their discovery that the 158V allele of this polymorphism can increase the risk of Cryptococcus infections up to 20-fold in homozygous individuals opens the possibility for risk stratification and personalized treatment of HIV-infected patients.
format	article
author	Mihai G. Netea
author_facet	Mihai G. Netea
author_sort	Mihai G. Netea
title	Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients
title_short	Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients
title_full	Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients
title_fullStr	Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients
title_full_unstemmed	Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients
title_sort	toward identification of the genetic risk profile for cryptococcal disease in hiv-infected patients
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/fb4f9e09f5f440db8bfced48faf72154
work_keys_str_mv	AT mihaignetea towardidentificationofthegeneticriskprofileforcryptococcaldiseaseinhivinfectedpatients
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Toward Identification of the Genetic Risk Profile for Cryptococcal Disease in HIV-Infected Patients

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