Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective r...

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Autores principales:	Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fb50d58e8455415e95e500de6612683f
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spelling	oai:doaj.org-article:fb50d58e8455415e95e500de6612683f2021-12-02T14:58:32ZSuper-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells10.1038/s42003-021-02126-w2399-3642https://doaj.org/article/fb50d58e8455415e95e500de6612683f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02126-whttps://doaj.org/toc/2399-3642Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective response by cells to protein aggregation.Jason C. SangEric HidariGeorg MeislRohan T. RanasingheMaria Grazia SpillantiniDavid KlenermanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jason C. Sang Eric Hidari Georg Meisl Rohan T. Ranasinghe Maria Grazia Spillantini David Klenerman Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
description	Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective response by cells to protein aggregation.
format	article
author	Jason C. Sang Eric Hidari Georg Meisl Rohan T. Ranasinghe Maria Grazia Spillantini David Klenerman
author_facet	Jason C. Sang Eric Hidari Georg Meisl Rohan T. Ranasinghe Maria Grazia Spillantini David Klenerman
author_sort	Jason C. Sang
title	Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
title_short	Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
title_full	Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
title_fullStr	Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
title_full_unstemmed	Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
title_sort	super-resolution imaging reveals α-synuclein seeded aggregation in sh-sy5y cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fb50d58e8455415e95e500de6612683f
work_keys_str_mv	AT jasoncsang superresolutionimagingrevealsasynucleinseededaggregationinshsy5ycells AT erichidari superresolutionimagingrevealsasynucleinseededaggregationinshsy5ycells AT georgmeisl superresolutionimagingrevealsasynucleinseededaggregationinshsy5ycells AT rohantranasinghe superresolutionimagingrevealsasynucleinseededaggregationinshsy5ycells AT mariagraziaspillantini superresolutionimagingrevealsasynucleinseededaggregationinshsy5ycells AT davidklenerman superresolutionimagingrevealsasynucleinseededaggregationinshsy5ycells
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Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

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