Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer

Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses to immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering the feasibility of sample collection, whether peripheral B cell signatures are associated with the responses to ICI th...

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Autores principales: Liliang Xia, Limin Guo, Jin Kang, Yi Yang, Yaxian Yao, Weimin Xia, Ruiming Sun, Shun Zhang, Wenfeng Li, Yuer Gao, Hongyan Chen, Ziming Li, Jinji Yang, Shun Lu, Ying Wang
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Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/fb538cfc95174cd095318619e326d25a
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spelling oai:doaj.org-article:fb538cfc95174cd095318619e326d25a2021-11-30T18:56:54ZPredictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer1664-322410.3389/fimmu.2021.759217https://doaj.org/article/fb538cfc95174cd095318619e326d25a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.759217/fullhttps://doaj.org/toc/1664-3224Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses to immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering the feasibility of sample collection, whether peripheral B cell signatures are associated with the responses to ICI therapy remains unclear. Herein, we have defined peripheral B cell signatures in advanced non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 monotherapy and investigated their associations with clinical efficacy. It was found that the percentages of B cells before the treatment (baseline) were significantly higher (P = 0.004) in responder (R, n = 17) than those in non-responder (NonR, n = 33) NSCLC patients in a discovery cohort. Moreover, the percentages of baseline IgM+ memory B cells were higher (P < 0.001) in R group than those in NonR group, and associated with a longer progression free survival (PFS) (P = 0.003). By logistic regression analysis peripheral baseline IgM+ memory B cells were identified as an independent prognostic factor (P = 0.002) for the prediction of the responses to anti-PD-1 monotherapy with the AUC value of 0.791, which was further validated in another anti-PD-1 monotherapy cohort (P = 0.011, n = 70) whereas no significance was observed in patients receiving anti-PD-L1 monotherapy (P = 0.135, n = 30). Therefore, our data suggest the roles of peripheral IgM+ memory B cells in predicting the responses to anti-PD-1 treatment in Chinese advanced NSCLC patients.Liliang XiaLiliang XiaLimin GuoJin KangYi YangYaxian YaoWeimin XiaRuiming SunShun ZhangWenfeng LiYuer GaoHongyan ChenZiming LiJinji YangShun LuYing WangFrontiers Media S.A.articleimmune checkpoint inhibitorsPD-1peripheral IgM+ memory B cellsresponse predictionadvanced NSCLCImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution DOAJ
collection DOAJ
language EN
topic immune checkpoint inhibitors
PD-1
peripheral IgM+ memory B cells
response prediction
advanced NSCLC
Immunologic diseases. Allergy
RC581-607
spellingShingle immune checkpoint inhibitors
PD-1
peripheral IgM+ memory B cells
response prediction
advanced NSCLC
Immunologic diseases. Allergy
RC581-607
Liliang Xia
Liliang Xia
Limin Guo
Jin Kang
Yi Yang
Yaxian Yao
Weimin Xia
Ruiming Sun
Shun Zhang
Wenfeng Li
Yuer Gao
Hongyan Chen
Ziming Li
Jinji Yang
Shun Lu
Ying Wang
Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer
description Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses to immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering the feasibility of sample collection, whether peripheral B cell signatures are associated with the responses to ICI therapy remains unclear. Herein, we have defined peripheral B cell signatures in advanced non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 monotherapy and investigated their associations with clinical efficacy. It was found that the percentages of B cells before the treatment (baseline) were significantly higher (P = 0.004) in responder (R, n = 17) than those in non-responder (NonR, n = 33) NSCLC patients in a discovery cohort. Moreover, the percentages of baseline IgM+ memory B cells were higher (P < 0.001) in R group than those in NonR group, and associated with a longer progression free survival (PFS) (P = 0.003). By logistic regression analysis peripheral baseline IgM+ memory B cells were identified as an independent prognostic factor (P = 0.002) for the prediction of the responses to anti-PD-1 monotherapy with the AUC value of 0.791, which was further validated in another anti-PD-1 monotherapy cohort (P = 0.011, n = 70) whereas no significance was observed in patients receiving anti-PD-L1 monotherapy (P = 0.135, n = 30). Therefore, our data suggest the roles of peripheral IgM+ memory B cells in predicting the responses to anti-PD-1 treatment in Chinese advanced NSCLC patients.
format article
author Liliang Xia
Liliang Xia
Limin Guo
Jin Kang
Yi Yang
Yaxian Yao
Weimin Xia
Ruiming Sun
Shun Zhang
Wenfeng Li
Yuer Gao
Hongyan Chen
Ziming Li
Jinji Yang
Shun Lu
Ying Wang
author_facet Liliang Xia
Liliang Xia
Limin Guo
Jin Kang
Yi Yang
Yaxian Yao
Weimin Xia
Ruiming Sun
Shun Zhang
Wenfeng Li
Yuer Gao
Hongyan Chen
Ziming Li
Jinji Yang
Shun Lu
Ying Wang
author_sort Liliang Xia
title Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer
title_short Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer
title_full Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer
title_fullStr Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer
title_full_unstemmed Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer
title_sort predictable roles of peripheral igm memory b cells for the responses to anti-pd-1 monotherapy against advanced non-small cell lung cancer
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/fb538cfc95174cd095318619e326d25a
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