Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer
Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses to immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering the feasibility of sample collection, whether peripheral B cell signatures are associated with the responses to ICI th...
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oai:doaj.org-article:fb538cfc95174cd095318619e326d25a2021-11-30T18:56:54ZPredictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer1664-322410.3389/fimmu.2021.759217https://doaj.org/article/fb538cfc95174cd095318619e326d25a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.759217/fullhttps://doaj.org/toc/1664-3224Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses to immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering the feasibility of sample collection, whether peripheral B cell signatures are associated with the responses to ICI therapy remains unclear. Herein, we have defined peripheral B cell signatures in advanced non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 monotherapy and investigated their associations with clinical efficacy. It was found that the percentages of B cells before the treatment (baseline) were significantly higher (P = 0.004) in responder (R, n = 17) than those in non-responder (NonR, n = 33) NSCLC patients in a discovery cohort. Moreover, the percentages of baseline IgM+ memory B cells were higher (P < 0.001) in R group than those in NonR group, and associated with a longer progression free survival (PFS) (P = 0.003). By logistic regression analysis peripheral baseline IgM+ memory B cells were identified as an independent prognostic factor (P = 0.002) for the prediction of the responses to anti-PD-1 monotherapy with the AUC value of 0.791, which was further validated in another anti-PD-1 monotherapy cohort (P = 0.011, n = 70) whereas no significance was observed in patients receiving anti-PD-L1 monotherapy (P = 0.135, n = 30). Therefore, our data suggest the roles of peripheral IgM+ memory B cells in predicting the responses to anti-PD-1 treatment in Chinese advanced NSCLC patients.Liliang XiaLiliang XiaLimin GuoJin KangYi YangYaxian YaoWeimin XiaRuiming SunShun ZhangWenfeng LiYuer GaoHongyan ChenZiming LiJinji YangShun LuYing WangFrontiers Media S.A.articleimmune checkpoint inhibitorsPD-1peripheral IgM+ memory B cellsresponse predictionadvanced NSCLCImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
institution |
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topic |
immune checkpoint inhibitors PD-1 peripheral IgM+ memory B cells response prediction advanced NSCLC Immunologic diseases. Allergy RC581-607 |
spellingShingle |
immune checkpoint inhibitors PD-1 peripheral IgM+ memory B cells response prediction advanced NSCLC Immunologic diseases. Allergy RC581-607 Liliang Xia Liliang Xia Limin Guo Jin Kang Yi Yang Yaxian Yao Weimin Xia Ruiming Sun Shun Zhang Wenfeng Li Yuer Gao Hongyan Chen Ziming Li Jinji Yang Shun Lu Ying Wang Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer |
description |
Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses to immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering the feasibility of sample collection, whether peripheral B cell signatures are associated with the responses to ICI therapy remains unclear. Herein, we have defined peripheral B cell signatures in advanced non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 monotherapy and investigated their associations with clinical efficacy. It was found that the percentages of B cells before the treatment (baseline) were significantly higher (P = 0.004) in responder (R, n = 17) than those in non-responder (NonR, n = 33) NSCLC patients in a discovery cohort. Moreover, the percentages of baseline IgM+ memory B cells were higher (P < 0.001) in R group than those in NonR group, and associated with a longer progression free survival (PFS) (P = 0.003). By logistic regression analysis peripheral baseline IgM+ memory B cells were identified as an independent prognostic factor (P = 0.002) for the prediction of the responses to anti-PD-1 monotherapy with the AUC value of 0.791, which was further validated in another anti-PD-1 monotherapy cohort (P = 0.011, n = 70) whereas no significance was observed in patients receiving anti-PD-L1 monotherapy (P = 0.135, n = 30). Therefore, our data suggest the roles of peripheral IgM+ memory B cells in predicting the responses to anti-PD-1 treatment in Chinese advanced NSCLC patients. |
format |
article |
author |
Liliang Xia Liliang Xia Limin Guo Jin Kang Yi Yang Yaxian Yao Weimin Xia Ruiming Sun Shun Zhang Wenfeng Li Yuer Gao Hongyan Chen Ziming Li Jinji Yang Shun Lu Ying Wang |
author_facet |
Liliang Xia Liliang Xia Limin Guo Jin Kang Yi Yang Yaxian Yao Weimin Xia Ruiming Sun Shun Zhang Wenfeng Li Yuer Gao Hongyan Chen Ziming Li Jinji Yang Shun Lu Ying Wang |
author_sort |
Liliang Xia |
title |
Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer |
title_short |
Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer |
title_full |
Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer |
title_fullStr |
Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer |
title_full_unstemmed |
Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer |
title_sort |
predictable roles of peripheral igm memory b cells for the responses to anti-pd-1 monotherapy against advanced non-small cell lung cancer |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/fb538cfc95174cd095318619e326d25a |
work_keys_str_mv |
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