Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.

Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.

Transgenic mice expressing the caspase-cleaved form of the tyrosine kinase Lyn (LynΔN) develop a TNFα-dependent skin disease that accurately recapitulates human psoriasis. Participation of lymphocytes in this disease was confirmed by backcrossing LynΔN mice on a Rag-1 deficient background. The prese...

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Autores principales: Nathalie Belhacéne, Parvati Gamas, Diogo Gonçalvès, Marie Jacquin, Marie Beneteau, Arnaud Jacquel, Pascal Colosetti, Jean-Ehrland Ricci, Abdellilah Wakkach, Patrick Auberger, Sandrine Marchetti
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fb568eaa08fd49bfa4c9ddadfe6c7f54
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